HCSGD entry for PTPN2

1. General information

Official gene symbolPTPN2
Entrez ID5771
Gene full nameprotein tyrosine phosphatase, non-receptor type 2
Other gene symbolsPTN2 PTPT TC-PTP TCELLPTP TCPTP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004725Protein tyrosine phosphatase activityIDA IEA IMPmolecular_function
GO:0005178Integrin bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005793Endoplasmic reticulum-Golgi intermediate compartmentIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0008152Metabolic processIDAbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0008286Insulin receptor signaling pathwayIEA ISSbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIEA ISSbiological_process
GO:0010888Negative regulation of lipid storageIEA ISSbiological_process
GO:0016311DephosphorylationIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019905Syntaxin bindingIPImolecular_function
GO:0030183B cell differentiationIEA ISSbiological_process
GO:0030217T cell differentiationIEA ISSbiological_process
GO:0030218Erythrocyte differentiationIEA ISSbiological_process
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0035335Peptidyl-tyrosine dephosphorylationIDA IMPbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayIMPbiological_process
GO:0042512Negative regulation of tyrosine phosphorylation of Stat1 proteinIDA IMPbiological_process
GO:0042518Negative regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042524Negative regulation of tyrosine phosphorylation of Stat5 proteinIEA ISSbiological_process
GO:0042527Negative regulation of tyrosine phosphorylation of Stat6 proteinIEA IMPbiological_process
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0045650Negative regulation of macrophage differentiationIEA ISSbiological_process
GO:0045722Positive regulation of gluconeogenesisIEA ISSbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIEA ISSbiological_process
GO:0050728Negative regulation of inflammatory responseIEA ISSbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIEA ISSbiological_process
GO:0050922Negative regulation of chemotaxisIEA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060336Negative regulation of interferon-gamma-mediated signaling pathwayIEA ISSbiological_process
GO:0060339Negative regulation of type I interferon-mediated signaling pathwayIEA IMPbiological_process
GO:0070104Negative regulation of interleukin-6-mediated signaling pathwayIEA IMPbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIEA ISSbiological_process
GO:1902202Regulation of hepatocyte growth factor receptor signaling pathwayIMPbiological_process
GO:1902206Negative regulation of interleukin-2-mediated signaling pathwayIEA IMPbiological_process
GO:1902212Negative regulation of prolactin signaling pathwayIEA ISSbiological_process
GO:1902215Negative regulation of interleukin-4-mediated signaling pathwayIEA IMPbiological_process
GO:1902227Negative regulation of macrophage colony-stimulating factor signaling pathwayIEA ISSbiological_process
GO:1902233Negative regulation of positive thymic T cell selectionIEA ISSbiological_process
GO:2000587Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84740311160.35200303940.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0074045660
GSE13712_SHEARUp0.0741031697
GSE13712_STATICUp0.1370007593
GSE19018Down-0.1105292839
GSE19899_A1Down-0.0357547226
GSE19899_A2Up0.3632746418
PubMed_21979375_A1Up0.1424370440
PubMed_21979375_A2Down-0.0538081902
GSE35957Down-0.0104106309
GSE36640Down-0.6650203042
GSE54402Up0.1124869098
GSE9593Down-0.0711744976
GSE43922Up0.0269941771
GSE24585Down-0.4109997521
GSE37065Down-0.0672971460
GSE28863_A1Up0.1633308616
GSE28863_A2Up0.0118341920
GSE28863_A3Down-0.2962330121
GSE28863_A4Down-0.0098458551
GSE48662Down-0.1428253120

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.