HCSGD entry for PTK6

1. General information

Official gene symbolPTK6
Entrez ID5753
Gene full nameprotein tyrosine kinase 6
Other gene symbolsBRK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0016477Cell migrationIDAbiological_process
GO:0042503Tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042506Tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0045926Negative regulation of growthIEAbiological_process
GO:0046777Protein autophosphorylationIMPbiological_process
GO:0060575Intestinal epithelial cell differentiationIEAbiological_process
GO:0061099Negative regulation of protein tyrosine kinase activityIDAbiological_process
GO:0071300Cellular response to retinoic acidIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45603391210.93584670800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0613965545
GSE13712_SHEARUp0.1014405291
GSE13712_STATICDown-0.0128664861
GSE19018Up0.3047571717
GSE19899_A1Up0.0221284418
GSE19899_A2Up0.2774124129
PubMed_21979375_A1Down-0.0089067883
PubMed_21979375_A2Up0.1246243722
GSE35957Up0.0391920569
GSE36640Up0.1419639620
GSE54402Down-0.0241780006
GSE9593Up0.0243642832
GSE43922Up0.1756771491
GSE24585Up0.0142936850
GSE37065Down-0.0110416220
GSE28863_A1Down-0.2188037297
GSE28863_A2Up0.0393286865
GSE28863_A3Up0.2331265582
GSE28863_A4Up0.0838117288
GSE48662Down-0.0272484532

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.