HCSGD entry for PTK6

1. General information

Official gene symbolPTK6
Entrez ID5753
Gene full nameprotein tyrosine kinase 6
Other gene symbolsBRK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0016477Cell migrationIDAbiological_process
GO:0042503Tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042506Tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0045926Negative regulation of growthIEAbiological_process
GO:0046777Protein autophosphorylationIMPbiological_process
GO:0060575Intestinal epithelial cell differentiationIEAbiological_process
GO:0061099Negative regulation of protein tyrosine kinase activityIDAbiological_process
GO:0071300Cellular response to retinoic acidIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45603391210.93584670800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0613965545
GSE13712_SHEARUp0.1014405291
GSE13712_STATICDown-0.0128664861
GSE19018Up0.3047571717
GSE19899_A1Up0.0221284418
GSE19899_A2Up0.2774124129
PubMed_21979375_A1Down-0.0089067883
PubMed_21979375_A2Up0.1246243722
GSE35957Up0.0391920569
GSE36640Up0.1419639620
GSE54402Down-0.0241780006
GSE9593Up0.0243642832
GSE43922Up0.1756771491
GSE24585Up0.0142936850
GSE37065Down-0.0110416220
GSE28863_A1Down-0.2188037297
GSE28863_A2Up0.0393286865
GSE28863_A3Up0.2331265582
GSE28863_A4Up0.0838117288
GSE48662Down-0.0272484532

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.