HCSGD entry for PSMC5

1. General information

Official gene symbolPSMC5
Entrez ID5705
Gene full nameproteasome (prosome, macropain) 26S subunit, ATPase, 5
Other gene symbolsS8 SUG-1 SUG1 TBP10 TRIP1 p45 p45/SUG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexIDAcellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0003712Transcription cofactor activityTASmolecular_function
GO:0005102Receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016234Inclusion bodyIEAcellular_component
GO:0016887ATPase activityIEA ISS TASmolecular_function
GO:0017025TBP-class protein bindingIEAmolecular_function
GO:0017111Nucleoside-triphosphatase activityIEAmolecular_function
GO:0022624Proteasome accessory complexIEA ISScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031531Thyrotropin-releasing hormone receptor bindingIPImolecular_function
GO:0031595Nuclear proteasome complexIEAcellular_component
GO:0031597Cytosolic proteasome complexIEAcellular_component
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043069Negative regulation of programmed cell deathNASbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0090261Positive regulation of inclusion body assemblyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14834548080.37510123860.77135547211.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6880318713
GSE13712_SHEARUp0.5325419203
GSE13712_STATICUp0.5862406621
GSE19018Down-0.5470116111
GSE19899_A1Down-0.1836532022
GSE19899_A2Down-0.1999934425
PubMed_21979375_A1Down-0.4739247674
PubMed_21979375_A2Down-0.5074132089
GSE35957Down-0.0699983091
GSE36640Down-0.1678331041
GSE54402Up0.4829815520
GSE9593Up0.0211189925
GSE43922Down-0.1248198541
GSE24585Up0.3689221545
GSE37065Down-0.1055645153
GSE28863_A1Up0.0247119167
GSE28863_A2Down-0.0258810345
GSE28863_A3Up0.2887436359
GSE28863_A4Up0.2510059147
GSE48662Down-0.2163558384

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1229-3pMIMAT0005584MIRT036390CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041377CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041740CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043146CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.