HCSGD entry for PSMC5

1. General information

Official gene symbolPSMC5
Entrez ID5705
Gene full nameproteasome (prosome, macropain) 26S subunit, ATPase, 5
Other gene symbolsS8 SUG-1 SUG1 TBP10 TRIP1 p45 p45/SUG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexIDAcellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0003712Transcription cofactor activityTASmolecular_function
GO:0005102Receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016234Inclusion bodyIEAcellular_component
GO:0016887ATPase activityIEA ISS TASmolecular_function
GO:0017025TBP-class protein bindingIEAmolecular_function
GO:0017111Nucleoside-triphosphatase activityIEAmolecular_function
GO:0022624Proteasome accessory complexIEA ISScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031531Thyrotropin-releasing hormone receptor bindingIPImolecular_function
GO:0031595Nuclear proteasome complexIEAcellular_component
GO:0031597Cytosolic proteasome complexIEAcellular_component
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043069Negative regulation of programmed cell deathNASbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0090261Positive regulation of inclusion body assemblyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14834548080.37510123860.77135547211.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6880318713
GSE13712_SHEARUp0.5325419203
GSE13712_STATICUp0.5862406621
GSE19018Down-0.5470116111
GSE19899_A1Down-0.1836532022
GSE19899_A2Down-0.1999934425
PubMed_21979375_A1Down-0.4739247674
PubMed_21979375_A2Down-0.5074132089
GSE35957Down-0.0699983091
GSE36640Down-0.1678331041
GSE54402Up0.4829815520
GSE9593Up0.0211189925
GSE43922Down-0.1248198541
GSE24585Up0.3689221545
GSE37065Down-0.1055645153
GSE28863_A1Up0.0247119167
GSE28863_A2Down-0.0258810345
GSE28863_A3Up0.2887436359
GSE28863_A4Up0.2510059147
GSE48662Down-0.2163558384

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1229-3pMIMAT0005584MIRT036390CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041377CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041740CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043146CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.