HCSGD entry for PRNP

1. General information

Official gene symbolPRNP
Entrez ID5621
Gene full nameprion protein
Other gene symbolsASCR AltPrP CD230 CJD GSS KURU PRIP PrP PrP27-30 PrP33-35C PrPc p27-30
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001933Negative regulation of protein phosphorylationIEA ISSbiological_process
GO:0005507Copper ion bindingIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005783Endoplasmic reticulumIEA ISScellular_component
GO:0005794Golgi apparatusIEA ISScellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0006878Cellular copper ion homeostasisNASbiological_process
GO:0006979Response to oxidative stressIEA ISSbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0008152Metabolic processTASbiological_process
GO:0015631Tubulin bindingIDAmolecular_function
GO:0019898Extrinsic component of membraneTAScellular_component
GO:0031225Anchored component of membraneIEAcellular_component
GO:0032689Negative regulation of interferon-gamma productionIEA ISSbiological_process
GO:0032700Negative regulation of interleukin-17 productionIEA ISSbiological_process
GO:0032703Negative regulation of interleukin-2 productionIEA ISSbiological_process
GO:0042802Identical protein bindingIEA IPImolecular_function
GO:0043008ATP-dependent protein bindingIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIEA ISSbiological_process
GO:0045121Membrane raftISScellular_component
GO:0046007Negative regulation of activated T cell proliferationIEA ISSbiological_process
GO:0046686Response to cadmium ionIEAbiological_process
GO:0046688Response to copper ionIEAbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIEA ISSbiological_process
GO:0051087Chaperone bindingIEAmolecular_function
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0070885Negative regulation of calcineurin-NFAT signaling cascadeIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00651273130.97420833930.21293523571.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2689086841
GSE13712_SHEARUp0.8124015894
GSE13712_STATICUp0.3458005345
GSE19018Up0.0008907259
GSE19899_A1Up0.1576844014
GSE19899_A2Up0.4168920162
PubMed_21979375_A1Up0.3211164520
PubMed_21979375_A2Down-0.2658656925
GSE35957Up0.6021756159
GSE36640Up1.8759653738
GSE54402Up0.0770215761
GSE9593Up1.0924423261
GSE43922Up0.3052708578
GSE24585Up0.4225053871
GSE37065Up0.0221974282
GSE28863_A1Down-0.2421437970
GSE28863_A2Up0.1764322315
GSE28863_A3Down-0.5423242154
GSE28863_A4Up0.2069780151
GSE48662Down-0.0260850596

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL39560CHEMBL48698P04156
CHEMBL643CHEMBL48698P04156
CHEMBL76CHEMBL48698P04156
CHEMBL71CHEMBL48698P04156
CHEMBL11CHEMBL48698P04156
CHEMBL564CHEMBL48698P04156
CHEMBL7568CHEMBL48698P04156
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  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016426MicroarrayFunctional MTI (Weak)20304954
hsa-miR-148b-3pMIMAT0000759MIRT019398MicroarrayFunctional MTI (Weak)17612493
hsa-miR-130b-3pMIMAT0000691MIRT020222SequencingFunctional MTI (Weak)20371350
hsa-miR-215-5pMIMAT0000272MIRT024424MicroarrayFunctional MTI (Weak)19074876
hsa-miR-148a-3pMIMAT0000243MIRT026010SequencingFunctional MTI (Weak)20371350
hsa-miR-192-5pMIMAT0000222MIRT026442MicroarrayFunctional MTI (Weak)19074876
hsa-miR-16-5pMIMAT0000069MIRT031685ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT040276CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25311131Since stepwise fibrillation of otherwise soluble proteins to insoluble amyloid-like protein aggregates is a hallmark of neurodegenerative protein-misfolding disorders including Alzheimer's disease, CAG repeat diseases, and the prion encephalopathies, investigation of intracellular amyloid may likewise aid to a better understanding of the pathomechanisms involved
23466301In particular, the expression levels of 9 genes, HSP90B1, EID1, ATP2B4, DDAH1, PRNP, RAB1A, PGS5, TM4SF1 and SSR3, gradually increased during senescence
15834659Studies using proteins relevant to multiple neurodegenerative conditions (prion, alpha-synuclein, huntingtin) have demonstrated the utility of S
12834113Because the AbetaPP transgene in Tg2576 mice is placed behind the PrP promoter, all amyloid-beta, including vascular amyloid, is considered to be of neuronal origin
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