HCSGD entry for PRNP

1. General information

Official gene symbolPRNP
Entrez ID5621
Gene full nameprion protein
Other gene symbolsASCR AltPrP CD230 CJD GSS KURU PRIP PrP PrP27-30 PrP33-35C PrPc p27-30
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001933Negative regulation of protein phosphorylationIEA ISSbiological_process
GO:0005507Copper ion bindingIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005783Endoplasmic reticulumIEA ISScellular_component
GO:0005794Golgi apparatusIEA ISScellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0006878Cellular copper ion homeostasisNASbiological_process
GO:0006979Response to oxidative stressIEA ISSbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0008152Metabolic processTASbiological_process
GO:0015631Tubulin bindingIDAmolecular_function
GO:0019898Extrinsic component of membraneTAScellular_component
GO:0031225Anchored component of membraneIEAcellular_component
GO:0032689Negative regulation of interferon-gamma productionIEA ISSbiological_process
GO:0032700Negative regulation of interleukin-17 productionIEA ISSbiological_process
GO:0032703Negative regulation of interleukin-2 productionIEA ISSbiological_process
GO:0042802Identical protein bindingIEA IPImolecular_function
GO:0043008ATP-dependent protein bindingIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIEA ISSbiological_process
GO:0045121Membrane raftISScellular_component
GO:0046007Negative regulation of activated T cell proliferationIEA ISSbiological_process
GO:0046686Response to cadmium ionIEAbiological_process
GO:0046688Response to copper ionIEAbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIEA ISSbiological_process
GO:0051087Chaperone bindingIEAmolecular_function
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0070885Negative regulation of calcineurin-NFAT signaling cascadeIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00651273130.97420833930.21293523571.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2689086841
GSE13712_SHEARUp0.8124015894
GSE13712_STATICUp0.3458005345
GSE19018Up0.0008907259
GSE19899_A1Up0.1576844014
GSE19899_A2Up0.4168920162
PubMed_21979375_A1Up0.3211164520
PubMed_21979375_A2Down-0.2658656925
GSE35957Up0.6021756159
GSE36640Up1.8759653738
GSE54402Up0.0770215761
GSE9593Up1.0924423261
GSE43922Up0.3052708578
GSE24585Up0.4225053871
GSE37065Up0.0221974282
GSE28863_A1Down-0.2421437970
GSE28863_A2Up0.1764322315
GSE28863_A3Down-0.5423242154
GSE28863_A4Up0.2069780151
GSE48662Down-0.0260850596

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL39560CHEMBL48698P04156
CHEMBL643CHEMBL48698P04156
CHEMBL76CHEMBL48698P04156
CHEMBL71CHEMBL48698P04156
CHEMBL11CHEMBL48698P04156
CHEMBL564CHEMBL48698P04156
CHEMBL7568CHEMBL48698P04156
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  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016426MicroarrayFunctional MTI (Weak)20304954
hsa-miR-148b-3pMIMAT0000759MIRT019398MicroarrayFunctional MTI (Weak)17612493
hsa-miR-130b-3pMIMAT0000691MIRT020222SequencingFunctional MTI (Weak)20371350
hsa-miR-215-5pMIMAT0000272MIRT024424MicroarrayFunctional MTI (Weak)19074876
hsa-miR-148a-3pMIMAT0000243MIRT026010SequencingFunctional MTI (Weak)20371350
hsa-miR-192-5pMIMAT0000222MIRT026442MicroarrayFunctional MTI (Weak)19074876
hsa-miR-16-5pMIMAT0000069MIRT031685ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT040276CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25311131Since stepwise fibrillation of otherwise soluble proteins to insoluble amyloid-like protein aggregates is a hallmark of neurodegenerative protein-misfolding disorders including Alzheimer's disease, CAG repeat diseases, and the prion encephalopathies, investigation of intracellular amyloid may likewise aid to a better understanding of the pathomechanisms involved
23466301In particular, the expression levels of 9 genes, HSP90B1, EID1, ATP2B4, DDAH1, PRNP, RAB1A, PGS5, TM4SF1 and SSR3, gradually increased during senescence
15834659Studies using proteins relevant to multiple neurodegenerative conditions (prion, alpha-synuclein, huntingtin) have demonstrated the utility of S
12834113Because the AbetaPP transgene in Tg2576 mice is placed behind the PrP promoter, all amyloid-beta, including vascular amyloid, is considered to be of neuronal origin
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