HCSGD entry for MAP2K7

1. General information

Official gene symbolMAP2K7
Entrez ID5609
Gene full namemitogen-activated protein kinase kinase 7
Other gene symbolsJnkk2 MAPKK7 MKK7 PRKMK7 SAPKK-4 SAPKK4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004708MAP kinase kinase activityIDAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0006950Response to stressIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007257Activation of JUN kinase activityISSbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008545JUN kinase kinase activityIEAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019903Protein phosphatase bindingISSmolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIEAmolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051403Stress-activated MAPK cascadeIDA TASbiological_process
GO:0072709Cellular response to sorbitolIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27087647510.90753443640.96807272601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0488836604
GSE13712_SHEARUp0.2176576516
GSE13712_STATICUp0.0658029720
GSE19018Up0.1157353517
GSE19899_A1Up0.0527225929
GSE19899_A2Up0.4918957806
PubMed_21979375_A1Up0.5911477608
PubMed_21979375_A2Up0.0208039502
GSE35957Up0.0399607994
GSE36640Up0.0840486597
GSE54402Up0.1750604561
GSE9593Down-0.1304254552
GSE43922Up0.3155700060
GSE24585Down-0.2982745594
GSE37065Down-0.1463064862
GSE28863_A1Down-0.1287749179
GSE28863_A2Down-0.0329594255
GSE28863_A3Up0.3379728783
GSE28863_A4Up0.0703850661
GSE48662Up0.1101648328

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT045769CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15107616Stress kinase MKK7: savior of cell cycle arrest and cellular senescence
15107616We further explored other molecules involved in JNK pathway and found that both MKK4, another direct activator of JNK, and c-Jun, a direct substrate of JNK, have similar roles to MKK7
15039780MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence
15039780Here we show that genetic inactivation of the stress signalling kinase, MKK7, a direct activator of JNKs in mice, results in embryonic lethality and impaired proliferation of hepatocytes
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