HCSGD entry for MAP2K7

1. General information

Official gene symbolMAP2K7
Entrez ID5609
Gene full namemitogen-activated protein kinase kinase 7
Other gene symbolsJnkk2 MAPKK7 MKK7 PRKMK7 SAPKK-4 SAPKK4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004708MAP kinase kinase activityIDAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0006950Response to stressIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007257Activation of JUN kinase activityISSbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008545JUN kinase kinase activityIEAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019903Protein phosphatase bindingISSmolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIEAmolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051403Stress-activated MAPK cascadeIDA TASbiological_process
GO:0072709Cellular response to sorbitolIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27087647510.90753443640.96807272601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0488836604
GSE13712_SHEARUp0.2176576516
GSE13712_STATICUp0.0658029720
GSE19018Up0.1157353517
GSE19899_A1Up0.0527225929
GSE19899_A2Up0.4918957806
PubMed_21979375_A1Up0.5911477608
PubMed_21979375_A2Up0.0208039502
GSE35957Up0.0399607994
GSE36640Up0.0840486597
GSE54402Up0.1750604561
GSE9593Down-0.1304254552
GSE43922Up0.3155700060
GSE24585Down-0.2982745594
GSE37065Down-0.1463064862
GSE28863_A1Down-0.1287749179
GSE28863_A2Down-0.0329594255
GSE28863_A3Up0.3379728783
GSE28863_A4Up0.0703850661
GSE48662Up0.1101648328

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT045769CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15107616Stress kinase MKK7: savior of cell cycle arrest and cellular senescence
15107616We further explored other molecules involved in JNK pathway and found that both MKK4, another direct activator of JNK, and c-Jun, a direct substrate of JNK, have similar roles to MKK7
15039780MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence
15039780Here we show that genetic inactivation of the stress signalling kinase, MKK7, a direct activator of JNKs in mice, results in embryonic lethality and impaired proliferation of hepatocytes
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