HCSGD entry for MAP2K6

1. General information

Official gene symbolMAP2K6
Entrez ID5608
Gene full namemitogen-activated protein kinase kinase 6
Other gene symbolsMAPKK6 MEK6 MKK6 PRKMK6 SAPKK-3 SAPKK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0002931Response to ischemiaIEAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIBAmolecular_function
GO:0004708MAP kinase kinase activityIBA IEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006975DNA damage induced protein phosphorylationTASbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0072709Cellular response to sorbitolIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97319223810.02541019720.99999024730.3063789931

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0180624693
GSE13712_SHEARDown-0.3646139543
GSE13712_STATICDown-0.1488502787
GSE19018Down-0.0633312345
GSE19899_A1Down-0.1017017129
GSE19899_A2Down-0.9322886361
PubMed_21979375_A1Down-0.7718067474
PubMed_21979375_A2Up0.0891982648
GSE35957Up0.0561666487
GSE36640Down-1.5060406129
GSE54402Down-0.6679139396
GSE9593Down-0.3414156670
GSE43922Down-0.6512155432
GSE24585Down-0.4047106813
GSE37065Down-0.1237387841
GSE28863_A1Up0.0887563130
GSE28863_A2Down-0.0307310549
GSE28863_A3Up0.1493794295
GSE28863_A4Down-0.0646941483
GSE48662Up0.4750153754

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-425-5pMIMAT0003393MIRT016670SequencingFunctional MTI (Weak)20371350
hsa-miR-145-5pMIMAT0000437MIRT021513Reporter assay;MicroarrayFunctional MTI21351259
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

12208764Here we demonstrate that stable expression of an activated form of MKK6 (MKK6EE), a direct activator of the stress-induced p38(HOG) mitogen-activated protein kinase pathway, is sufficient for inducing features of senescence including a flattened, vacuolated, and irregular morphology, staining for acidic beta-galactosidase, and accumulation of age-associated pigments
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