HCSGD entry for MAP2K6

1. General information

Official gene symbolMAP2K6
Entrez ID5608
Gene full namemitogen-activated protein kinase kinase 6
Other gene symbolsMAPKK6 MEK6 MKK6 PRKMK6 SAPKK-3 SAPKK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0002931Response to ischemiaIEAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIBAmolecular_function
GO:0004708MAP kinase kinase activityIBA IEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006975DNA damage induced protein phosphorylationTASbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0072709Cellular response to sorbitolIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97319223810.02541019720.99999024730.3063789931

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0180624693
GSE13712_SHEARDown-0.3646139543
GSE13712_STATICDown-0.1488502787
GSE19018Down-0.0633312345
GSE19899_A1Down-0.1017017129
GSE19899_A2Down-0.9322886361
PubMed_21979375_A1Down-0.7718067474
PubMed_21979375_A2Up0.0891982648
GSE35957Up0.0561666487
GSE36640Down-1.5060406129
GSE54402Down-0.6679139396
GSE9593Down-0.3414156670
GSE43922Down-0.6512155432
GSE24585Down-0.4047106813
GSE37065Down-0.1237387841
GSE28863_A1Up0.0887563130
GSE28863_A2Down-0.0307310549
GSE28863_A3Up0.1493794295
GSE28863_A4Down-0.0646941483
GSE48662Up0.4750153754

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-425-5pMIMAT0003393MIRT016670SequencingFunctional MTI (Weak)20371350
hsa-miR-145-5pMIMAT0000437MIRT021513Reporter assay;MicroarrayFunctional MTI21351259
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

12208764Here we demonstrate that stable expression of an activated form of MKK6 (MKK6EE), a direct activator of the stress-induced p38(HOG) mitogen-activated protein kinase pathway, is sufficient for inducing features of senescence including a flattened, vacuolated, and irregular morphology, staining for acidic beta-galactosidase, and accumulation of age-associated pigments
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