HCSGD entry for MAP2K5

1. General information

Official gene symbolMAP2K5
Entrez ID5607
Gene full namemitogen-activated protein kinase kinase 5
Other gene symbolsHsT17454 MAPKK5 MEK5 PRKMK5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0000187Activation of MAPK activityIEA ISSbiological_process
GO:0004672Protein kinase activityIEA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIEA ISSbiological_process
GO:0034115Negative regulation of heterotypic cell-cell adhesionIEA ISSbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA ISSbiological_process
GO:0045415Negative regulation of interleukin-8 biosynthetic processIEA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0051247Positive regulation of protein metabolic processISSbiological_process
GO:0060761Negative regulation of response to cytokine stimulusIEA ISSbiological_process
GO:0070375ERK5 cascadeIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEA ISSbiological_process
GO:0071499Cellular response to laminar fluid shear stressTASbiological_process
GO:0090051Negative regulation of cell migration involved in sprouting angiogenesisIEA ISSbiological_process
GO:2000342Negative regulation of chemokine (C-X-C motif) ligand 2 productionIEA ISSbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65342944800.59719991260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0147973344
GSE13712_SHEARDown-0.4063458215
GSE13712_STATICDown-0.0689484673
GSE19018Up0.1192825224
GSE19899_A1Down-0.0542726223
GSE19899_A2Down-0.0803215753
PubMed_21979375_A1Down-0.4989802231
PubMed_21979375_A2Up0.1245030589
GSE35957Up0.0926978612
GSE36640Down-0.0566703137
GSE54402Down-0.1096742694
GSE9593Up0.0516410361
GSE43922Down-0.0570313089
GSE24585Up0.0223652729
GSE37065Up0.0492715964
GSE28863_A1Up0.7031290653
GSE28863_A2Up0.1339189129
GSE28863_A3Up0.0097533044
GSE28863_A4Down-0.0056462343
GSE48662Up0.2775642670

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018716MicroarrayFunctional MTI (Weak)18185580
hsa-miR-214-3pMIMAT0000271MIRT024959Microarray;OtherFunctional MTI (Weak)19859982
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.