HCSGD entry for MAP2K5

1. General information

Official gene symbolMAP2K5
Entrez ID5607
Gene full namemitogen-activated protein kinase kinase 5
Other gene symbolsHsT17454 MAPKK5 MEK5 PRKMK5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0000187Activation of MAPK activityIEA ISSbiological_process
GO:0004672Protein kinase activityIEA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIEA ISSbiological_process
GO:0034115Negative regulation of heterotypic cell-cell adhesionIEA ISSbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA ISSbiological_process
GO:0045415Negative regulation of interleukin-8 biosynthetic processIEA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0051247Positive regulation of protein metabolic processISSbiological_process
GO:0060761Negative regulation of response to cytokine stimulusIEA ISSbiological_process
GO:0070375ERK5 cascadeIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEA ISSbiological_process
GO:0071499Cellular response to laminar fluid shear stressTASbiological_process
GO:0090051Negative regulation of cell migration involved in sprouting angiogenesisIEA ISSbiological_process
GO:2000342Negative regulation of chemokine (C-X-C motif) ligand 2 productionIEA ISSbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65342944800.59719991260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0147973344
GSE13712_SHEARDown-0.4063458215
GSE13712_STATICDown-0.0689484673
GSE19018Up0.1192825224
GSE19899_A1Down-0.0542726223
GSE19899_A2Down-0.0803215753
PubMed_21979375_A1Down-0.4989802231
PubMed_21979375_A2Up0.1245030589
GSE35957Up0.0926978612
GSE36640Down-0.0566703137
GSE54402Down-0.1096742694
GSE9593Up0.0516410361
GSE43922Down-0.0570313089
GSE24585Up0.0223652729
GSE37065Up0.0492715964
GSE28863_A1Up0.7031290653
GSE28863_A2Up0.1339189129
GSE28863_A3Up0.0097533044
GSE28863_A4Down-0.0056462343
GSE48662Up0.2775642670

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018716MicroarrayFunctional MTI (Weak)18185580
hsa-miR-214-3pMIMAT0000271MIRT024959Microarray;OtherFunctional MTI (Weak)19859982
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.