HCSGD entry for MAPK7

1. General information

Official gene symbolMAPK7
Entrez ID5598
Gene full namemitogen-activated protein kinase 7
Other gene symbolsBMK1 ERK4 ERK5 PRKM7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0007049Cell cycleIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0018105Peptidyl-serine phosphorylationIEAbiological_process
GO:0019933CAMP-mediated signalingNASbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030821Negative regulation of cAMP catabolic processNASbiological_process
GO:0034115Negative regulation of heterotypic cell-cell adhesionIGIbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0036003Positive regulation of transcription from RNA polymerase II promoter in response to stressIMPbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045765Regulation of angiogenesisIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIGIbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050728Negative regulation of inflammatory responseTASbiological_process
GO:0051019Mitogen-activated protein kinase bindingIPImolecular_function
GO:0051247Positive regulation of protein metabolic processIGIbiological_process
GO:0051344Negative regulation of cyclic-nucleotide phosphodiesterase activityNASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0051534Negative regulation of NFAT protein import into nucleusIEAbiological_process
GO:0060761Negative regulation of response to cytokine stimulusIGIbiological_process
GO:0070301Cellular response to hydrogen peroxideIMPbiological_process
GO:0071363Cellular response to growth factor stimulusIGIbiological_process
GO:0071499Cellular response to laminar fluid shear stressIMP TASbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:1902176Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIMPbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIMPbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIGIbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28411528060.62082828540.98308830641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0873653480
GSE13712_SHEARDown-0.0390239452
GSE13712_STATICUp0.1569969259
GSE19018Down-0.0995150032
GSE19899_A1Down-0.3837943052
GSE19899_A2Down-0.1739751968
PubMed_21979375_A1Up0.4010837114
PubMed_21979375_A2Up0.8171618845
GSE35957Down-0.3562693454
GSE36640Up0.0333639293
GSE54402Down-0.0136349755
GSE9593Up0.1194572736
GSE43922Up0.0516335400
GSE24585Up0.0983319459
GSE37065Up0.0656753951
GSE28863_A1Up0.2431321096
GSE28863_A2Up0.2328987277
GSE28863_A3Up0.1490905917
GSE28863_A4Down-0.1547476309
GSE48662Up0.1941790003

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-143-3pMIMAT0000435MIRT003759In situ hybridization//qRT-PCR//Western blotFunctional MTI17504027
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotNon-Functional MTI19157460
hsa-miR-143-3pMIMAT0000435MIRT003759Western blot//Luciferase reporter assay//Western blot;OtherFunctional MTI19464056
hsa-miR-143-3pMIMAT0000435MIRT003759Luciferase reporter assay//Western blotFunctional MTI19855844
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotFunctional MTI17892514
hsa-miR-143-3pMIMAT0000435MIRT003759Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blotFunctional MTI15504739
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotFunctional MTI16966691
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotFunctional MTI16969504
hsa-miR-143-3pMIMAT0000435MIRT003759Western blotFunctional MTI23276710
hsa-miR-143-3pMIMAT0000435MIRT003759Western blotFunctional MTI19843160
hsa-miR-744-5pMIMAT0004945MIRT037532CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038446CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-143-3pMIMAT0000435NAhsa-miR-143{Western blot}{underexpression by anti-miRNA oligonucleotides}15504739
hsa-miR-143-3pMIMAT00004351hsa-miR-143{Western blot}{overexpression by miRNA precursor transfection}19855844
hsa-miR-143-3pMIMAT0000435NAhsa-miR-143{Western blot}{overexpression by miRNA mimics tranfection}19439999
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26443543ERK5/HDAC5-mediated, resveratrol-, and pterostilbene-induced expression of MnSOD in human endothelial cells
26443543Similarly, two stilbenes also stimulated LKB1, AMPKalpha, extracellular-signal related kinase 5 (ERK5) phosphorylation, and histone acetylase 5 (HDAC5) and Kruppel-like factor 2 (KLF2) expression
26443543CONCLUSION: Resveratrol and pterostilbene can activate MnSOD expression through ERK5/HDAC5 pathway, thus alleviating mitochondrial oxidative stress in endothelial cells that relates to cardiovascular disease
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