HCSGD entry for MAPK7

1. General information

Official gene symbolMAPK7
Entrez ID5598
Gene full namemitogen-activated protein kinase 7
Other gene symbolsBMK1 ERK4 ERK5 PRKM7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0007049Cell cycleIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0018105Peptidyl-serine phosphorylationIEAbiological_process
GO:0019933CAMP-mediated signalingNASbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030821Negative regulation of cAMP catabolic processNASbiological_process
GO:0034115Negative regulation of heterotypic cell-cell adhesionIGIbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0036003Positive regulation of transcription from RNA polymerase II promoter in response to stressIMPbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045765Regulation of angiogenesisIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIGIbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050728Negative regulation of inflammatory responseTASbiological_process
GO:0051019Mitogen-activated protein kinase bindingIPImolecular_function
GO:0051247Positive regulation of protein metabolic processIGIbiological_process
GO:0051344Negative regulation of cyclic-nucleotide phosphodiesterase activityNASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0051534Negative regulation of NFAT protein import into nucleusIEAbiological_process
GO:0060761Negative regulation of response to cytokine stimulusIGIbiological_process
GO:0070301Cellular response to hydrogen peroxideIMPbiological_process
GO:0071363Cellular response to growth factor stimulusIGIbiological_process
GO:0071499Cellular response to laminar fluid shear stressIMP TASbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:1902176Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIMPbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIMPbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIGIbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28411528060.62082828540.98308830641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0873653480
GSE13712_SHEARDown-0.0390239452
GSE13712_STATICUp0.1569969259
GSE19018Down-0.0995150032
GSE19899_A1Down-0.3837943052
GSE19899_A2Down-0.1739751968
PubMed_21979375_A1Up0.4010837114
PubMed_21979375_A2Up0.8171618845
GSE35957Down-0.3562693454
GSE36640Up0.0333639293
GSE54402Down-0.0136349755
GSE9593Up0.1194572736
GSE43922Up0.0516335400
GSE24585Up0.0983319459
GSE37065Up0.0656753951
GSE28863_A1Up0.2431321096
GSE28863_A2Up0.2328987277
GSE28863_A3Up0.1490905917
GSE28863_A4Down-0.1547476309
GSE48662Up0.1941790003

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-143-3pMIMAT0000435MIRT003759In situ hybridization//qRT-PCR//Western blotFunctional MTI17504027
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotNon-Functional MTI19157460
hsa-miR-143-3pMIMAT0000435MIRT003759Western blot//Luciferase reporter assay//Western blot;OtherFunctional MTI19464056
hsa-miR-143-3pMIMAT0000435MIRT003759Luciferase reporter assay//Western blotFunctional MTI19855844
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotFunctional MTI17892514
hsa-miR-143-3pMIMAT0000435MIRT003759Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blotFunctional MTI15504739
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotFunctional MTI16966691
hsa-miR-143-3pMIMAT0000435MIRT003759qRT-PCR//Western blotFunctional MTI16969504
hsa-miR-143-3pMIMAT0000435MIRT003759Western blotFunctional MTI23276710
hsa-miR-143-3pMIMAT0000435MIRT003759Western blotFunctional MTI19843160
hsa-miR-744-5pMIMAT0004945MIRT037532CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038446CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-143-3pMIMAT0000435NAhsa-miR-143{Western blot}{underexpression by anti-miRNA oligonucleotides}15504739
hsa-miR-143-3pMIMAT00004351hsa-miR-143{Western blot}{overexpression by miRNA precursor transfection}19855844
hsa-miR-143-3pMIMAT0000435NAhsa-miR-143{Western blot}{overexpression by miRNA mimics tranfection}19439999
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26443543ERK5/HDAC5-mediated, resveratrol-, and pterostilbene-induced expression of MnSOD in human endothelial cells
26443543Similarly, two stilbenes also stimulated LKB1, AMPKalpha, extracellular-signal related kinase 5 (ERK5) phosphorylation, and histone acetylase 5 (HDAC5) and Kruppel-like factor 2 (KLF2) expression
26443543CONCLUSION: Resveratrol and pterostilbene can activate MnSOD expression through ERK5/HDAC5 pathway, thus alleviating mitochondrial oxidative stress in endothelial cells that relates to cardiovascular disease
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