HCSGD entry for PRKCD

1. General information

Official gene symbolPRKCD
Entrez ID5580
Gene full nameprotein kinase C, delta
Other gene symbolsMAY1 PKCD nPKC-delta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004697Protein kinase C activityIEA ISSmolecular_function
GO:0004699Calcium-independent protein kinase C activityTASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005911Cell-cell junctionIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processIDA TASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008047Enzyme activator activityIDAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010469Regulation of receptor activityTASbiological_process
GO:0016064Immunoglobulin mediated immune responseIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016363Nuclear matrixIEAcellular_component
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0023021Termination of signal transductionIMPbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030837Negative regulation of actin filament polymerizationIEA ISSbiological_process
GO:0032091Negative regulation of protein bindingTASbiological_process
GO:0032613Interleukin-10 productionIEAbiological_process
GO:0032615Interleukin-12 productionIEAbiological_process
GO:0032930Positive regulation of superoxide anion generationIMPbiological_process
GO:0034351Negative regulation of glial cell apoptotic processIMPbiological_process
GO:0035307Positive regulation of protein dephosphorylationIMPbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042100B cell proliferationIEAbiological_process
GO:0042119Neutrophil activationIDAbiological_process
GO:0042742Defense response to bacteriumIEA ISSbiological_process
GO:0043407Negative regulation of MAP kinase activityIMPbiological_process
GO:0043560Insulin receptor substrate bindingIEA ISSmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIEA ISS TASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050728Negative regulation of inflammatory responseICbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIEA ISSbiological_process
GO:0050821Protein stabilizationNASbiological_process
GO:0051490Negative regulation of filopodium assemblyIEA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0090331Negative regulation of platelet aggregationIEA ISSbiological_process
GO:0090398Cellular senescenceIMPbiological_process
GO:1900163Positive regulation of phospholipid scramblase activityIMPbiological_process
GO:2000304Positive regulation of ceramide biosynthetic processIMPbiological_process
GO:2000753Positive regulation of glucosylceramide catabolic processIMPbiological_process
GO:2000755Positive regulation of sphingomyelin catabolic processIMPbiological_process
GO:2001022Positive regulation of response to DNA damage stimulusIMPbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01012564870.89343848640.25614457251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1818785186
GSE13712_SHEARUp0.9511881239
GSE13712_STATICUp1.2446464359
GSE19018Up0.2956200775
GSE19899_A1Up0.0615371021
GSE19899_A2Up1.2910145129
PubMed_21979375_A1Up0.4858396975
PubMed_21979375_A2Up1.6660096800
GSE35957Down-0.7250812737
GSE36640Down-0.0391797768
GSE54402Up0.4661539873
GSE9593Up0.4046703751
GSE43922Up0.5311463807
GSE24585Down-0.5157799195
GSE37065Up0.2734485882
GSE28863_A1Down-0.1650407739
GSE28863_A2Up0.1526110048
GSE28863_A3Up0.0058790682
GSE28863_A4Up0.0325786302
GSE48662Up0.1088438872

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

13-AcetylphorbolDB04376 EXPT02656
Ingenol MebutateDB05013 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT039609CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041814CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.