HCSGD entry for PRKCD

1. General information

Official gene symbolPRKCD
Entrez ID5580
Gene full nameprotein kinase C, delta
Other gene symbolsMAY1 PKCD nPKC-delta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004697Protein kinase C activityIEA ISSmolecular_function
GO:0004699Calcium-independent protein kinase C activityTASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005911Cell-cell junctionIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processIDA TASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008047Enzyme activator activityIDAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010469Regulation of receptor activityTASbiological_process
GO:0016064Immunoglobulin mediated immune responseIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016363Nuclear matrixIEAcellular_component
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0023021Termination of signal transductionIMPbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030837Negative regulation of actin filament polymerizationIEA ISSbiological_process
GO:0032091Negative regulation of protein bindingTASbiological_process
GO:0032613Interleukin-10 productionIEAbiological_process
GO:0032615Interleukin-12 productionIEAbiological_process
GO:0032930Positive regulation of superoxide anion generationIMPbiological_process
GO:0034351Negative regulation of glial cell apoptotic processIMPbiological_process
GO:0035307Positive regulation of protein dephosphorylationIMPbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042100B cell proliferationIEAbiological_process
GO:0042119Neutrophil activationIDAbiological_process
GO:0042742Defense response to bacteriumIEA ISSbiological_process
GO:0043407Negative regulation of MAP kinase activityIMPbiological_process
GO:0043560Insulin receptor substrate bindingIEA ISSmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIEA ISS TASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050728Negative regulation of inflammatory responseICbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIEA ISSbiological_process
GO:0050821Protein stabilizationNASbiological_process
GO:0051490Negative regulation of filopodium assemblyIEA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0090331Negative regulation of platelet aggregationIEA ISSbiological_process
GO:0090398Cellular senescenceIMPbiological_process
GO:1900163Positive regulation of phospholipid scramblase activityIMPbiological_process
GO:2000304Positive regulation of ceramide biosynthetic processIMPbiological_process
GO:2000753Positive regulation of glucosylceramide catabolic processIMPbiological_process
GO:2000755Positive regulation of sphingomyelin catabolic processIMPbiological_process
GO:2001022Positive regulation of response to DNA damage stimulusIMPbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01012564870.89343848640.25614457251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1818785186
GSE13712_SHEARUp0.9511881239
GSE13712_STATICUp1.2446464359
GSE19018Up0.2956200775
GSE19899_A1Up0.0615371021
GSE19899_A2Up1.2910145129
PubMed_21979375_A1Up0.4858396975
PubMed_21979375_A2Up1.6660096800
GSE35957Down-0.7250812737
GSE36640Down-0.0391797768
GSE54402Up0.4661539873
GSE9593Up0.4046703751
GSE43922Up0.5311463807
GSE24585Down-0.5157799195
GSE37065Up0.2734485882
GSE28863_A1Down-0.1650407739
GSE28863_A2Up0.1526110048
GSE28863_A3Up0.0058790682
GSE28863_A4Up0.0325786302
GSE48662Up0.1088438872

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

13-AcetylphorbolDB04376 EXPT02656
Ingenol MebutateDB05013 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT039609CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041814CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.