HCSGD entry for PRKAR2B

1. General information

Official gene symbolPRKAR2B
Entrez ID5577
Gene full nameprotein kinase, cAMP-dependent, regulatory, type II, beta
Other gene symbolsPRKAR2 RII-BETA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004862CAMP-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005952CAMP-dependent protein kinase complexIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006631Fatty acid metabolic processIEAbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007612LearningIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityIDAmolecular_function
GO:0030552CAMP bindingIEAmolecular_function
GO:0031625Ubiquitin protein ligase bindingIDAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0035556Intracellular signal transductionTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96964801110.00039068040.99999024730.0365946619

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5986808957
GSE13712_SHEARDown-0.3204754642
GSE13712_STATICDown-0.1202731580
GSE19018Down-2.8162714075
GSE19899_A1Down-1.4881362992
GSE19899_A2Down-2.2580028469
PubMed_21979375_A1Down-2.3833086058
PubMed_21979375_A2Down-2.4991333141
GSE35957Down-0.4158259632
GSE36640Down-0.0079036415
GSE54402Down-1.0641433135
GSE9593Down-1.6363638409
GSE43922Down-0.7918961742
GSE24585Down-0.1527600466
GSE37065Up0.2941792269
GSE28863_A1Down-0.2935558668
GSE28863_A2Down-0.3807930166
GSE28863_A3Up0.2549008492
GSE28863_A4Down-0.2679329716
GSE48662Up0.1905395563

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Cyclic Adenosine MonophosphateDB02527 EXPT00959

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-590-3pMIMAT0004801MIRT016228SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.