HCSGD entry for PRKAR2B

1. General information

Official gene symbolPRKAR2B
Entrez ID5577
Gene full nameprotein kinase, cAMP-dependent, regulatory, type II, beta
Other gene symbolsPRKAR2 RII-BETA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004862CAMP-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005952CAMP-dependent protein kinase complexIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006631Fatty acid metabolic processIEAbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007612LearningIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityIDAmolecular_function
GO:0030552CAMP bindingIEAmolecular_function
GO:0031625Ubiquitin protein ligase bindingIDAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0035556Intracellular signal transductionTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96964801110.00039068040.99999024730.0365946619

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5986808957
GSE13712_SHEARDown-0.3204754642
GSE13712_STATICDown-0.1202731580
GSE19018Down-2.8162714075
GSE19899_A1Down-1.4881362992
GSE19899_A2Down-2.2580028469
PubMed_21979375_A1Down-2.3833086058
PubMed_21979375_A2Down-2.4991333141
GSE35957Down-0.4158259632
GSE36640Down-0.0079036415
GSE54402Down-1.0641433135
GSE9593Down-1.6363638409
GSE43922Down-0.7918961742
GSE24585Down-0.1527600466
GSE37065Up0.2941792269
GSE28863_A1Down-0.2935558668
GSE28863_A2Down-0.3807930166
GSE28863_A3Up0.2549008492
GSE28863_A4Down-0.2679329716
GSE48662Up0.1905395563

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Cyclic Adenosine MonophosphateDB02527 EXPT00959

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-590-3pMIMAT0004801MIRT016228SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.