HCSGD entry for PRKAR2A

1. General information

Official gene symbolPRKAR2A
Entrez ID5576
Gene full nameprotein kinase, cAMP-dependent, regulatory, type II, alpha
Other gene symbolsPKR2 PRKAR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004862CAMP-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005952CAMP-dependent protein kinase complexIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityIDA IEA NASmolecular_function
GO:0016020MembraneTAScellular_component
GO:0016301Kinase activityIEAmolecular_function
GO:0030552CAMP bindingIEAmolecular_function
GO:0031588AMP-activated protein kinase complexIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIDAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0035556Intracellular signal transductionTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19234467920.68453054980.85064464051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0921270880
GSE13712_SHEARDown-0.1499778099
GSE13712_STATICUp0.0457767838
GSE19018Down-0.0725847394
GSE19899_A1Up0.2785817106
GSE19899_A2Up0.3734793073
PubMed_21979375_A1Up0.3926368337
PubMed_21979375_A2Up0.2286276938
GSE35957Down-0.0203566953
GSE36640Down-0.0393449867
GSE54402Up0.3464992157
GSE9593Down-0.0116501289
GSE43922Up0.3164452081
GSE24585Up0.4589060005
GSE37065Down-0.3180561376
GSE28863_A1Up0.0764660625
GSE28863_A2Up0.1543401414
GSE28863_A3Down-0.8986405670
GSE28863_A4Down-0.2260134072
GSE48662Down-0.0493272115

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GEM-231DB05798 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004218MicroarrayFunctional MTI (Weak)16822819
hsa-miR-155-5pMIMAT0000646MIRT020699ProteomicsFunctional MTI (Weak)18668040
hsa-miR-103a-3pMIMAT0000101MIRT027082SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031655SequencingFunctional MTI (Weak)20371350
hsa-let-7b-5pMIMAT0000063MIRT032313ProteomicsFunctional MTI (Weak)18668040
hsa-miR-769-3pMIMAT0003887MIRT039067CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052717CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.