HCSGD entry for PRKAR2A

1. General information

Official gene symbolPRKAR2A
Entrez ID5576
Gene full nameprotein kinase, cAMP-dependent, regulatory, type II, alpha
Other gene symbolsPKR2 PRKAR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004862CAMP-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005952CAMP-dependent protein kinase complexIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityIDA IEA NASmolecular_function
GO:0016020MembraneTAScellular_component
GO:0016301Kinase activityIEAmolecular_function
GO:0030552CAMP bindingIEAmolecular_function
GO:0031588AMP-activated protein kinase complexIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIDAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0035556Intracellular signal transductionTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19234467920.68453054980.85064464051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0921270880
GSE13712_SHEARDown-0.1499778099
GSE13712_STATICUp0.0457767838
GSE19018Down-0.0725847394
GSE19899_A1Up0.2785817106
GSE19899_A2Up0.3734793073
PubMed_21979375_A1Up0.3926368337
PubMed_21979375_A2Up0.2286276938
GSE35957Down-0.0203566953
GSE36640Down-0.0393449867
GSE54402Up0.3464992157
GSE9593Down-0.0116501289
GSE43922Up0.3164452081
GSE24585Up0.4589060005
GSE37065Down-0.3180561376
GSE28863_A1Up0.0764660625
GSE28863_A2Up0.1543401414
GSE28863_A3Down-0.8986405670
GSE28863_A4Down-0.2260134072
GSE48662Down-0.0493272115

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GEM-231DB05798 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004218MicroarrayFunctional MTI (Weak)16822819
hsa-miR-155-5pMIMAT0000646MIRT020699ProteomicsFunctional MTI (Weak)18668040
hsa-miR-103a-3pMIMAT0000101MIRT027082SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031655SequencingFunctional MTI (Weak)20371350
hsa-let-7b-5pMIMAT0000063MIRT032313ProteomicsFunctional MTI (Weak)18668040
hsa-miR-769-3pMIMAT0003887MIRT039067CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052717CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.