HCSGD entry for PKIA

1. General information

Official gene symbolPKIA
Entrez ID5569
Gene full nameprotein kinase (cAMP-dependent, catalytic) inhibitor alpha
Other gene symbolsPRKACN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0004862CAMP-dependent protein kinase inhibitor activityIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0010389Regulation of G2/M transition of mitotic cell cycleIEAbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0042308Negative regulation of protein import into nucleusIEAbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02387971580.17727662320.36631637530.8141856570

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.3725312015
GSE13712_SHEARUp0.2104056168
GSE13712_STATICUp0.1517626594
GSE19018Down-0.0210161306
GSE19899_A1Up0.7338625888
GSE19899_A2Down-0.1961548586
PubMed_21979375_A1Up1.5429170315
PubMed_21979375_A2Up0.1801000350
GSE35957Down-1.1884659262
GSE36640Up0.0953733614
GSE54402Up1.1053353864
GSE9593Up0.3424534078
GSE43922Up0.5134026540
GSE24585Down-1.2857028643
GSE37065Up0.1650613418
GSE28863_A1Down-0.3896284046
GSE28863_A2Up0.0685011071
GSE28863_A3Down-0.0443655014
GSE28863_A4Down-0.1986886696
GSE48662Down-0.4739114872

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

3,5-DiiodotyrosineDB03374 EXPT03137
HYDROXYFASUDILDB04707 -
(1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINEDB06959 -
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINEDB07107 -
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINEDB07204 -
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINEDB07583 -
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDB07854 -
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDB07855 -
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINEDB07856 -
(2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDB07857 -
(2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDB07858 -
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDB07859 -
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINEDB07860 -
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINEDB07876 -
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDB07947 -
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDEDB07995 -
1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINEDB07996 -
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDEDB07997 -
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDB08070 -
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDB08073 -
3-pyridin-4-yl-1H-indazoleDB08113 -
5-benzyl-1,3-thiazol-2-amineDB08114 -
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDB08148 -
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDB08149 -
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminiumDB08150 -
5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINEDB08162 -
MYRISTIC ACIDDB08231 -
(2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINEDB08568 -
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLEDB08569 -
(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDEDB08756 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT006214ChIP-seq//Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22473996
hsa-miR-26b-5pMIMAT0000083MIRT030340MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.