HCSGD entry for PKIA

1. General information

Official gene symbolPKIA
Entrez ID5569
Gene full nameprotein kinase (cAMP-dependent, catalytic) inhibitor alpha
Other gene symbolsPRKACN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0004862CAMP-dependent protein kinase inhibitor activityIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0010389Regulation of G2/M transition of mitotic cell cycleIEAbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0042308Negative regulation of protein import into nucleusIEAbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02387971580.17727662320.36631637530.8141856570

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.3725312015
GSE13712_SHEARUp0.2104056168
GSE13712_STATICUp0.1517626594
GSE19018Down-0.0210161306
GSE19899_A1Up0.7338625888
GSE19899_A2Down-0.1961548586
PubMed_21979375_A1Up1.5429170315
PubMed_21979375_A2Up0.1801000350
GSE35957Down-1.1884659262
GSE36640Up0.0953733614
GSE54402Up1.1053353864
GSE9593Up0.3424534078
GSE43922Up0.5134026540
GSE24585Down-1.2857028643
GSE37065Up0.1650613418
GSE28863_A1Down-0.3896284046
GSE28863_A2Up0.0685011071
GSE28863_A3Down-0.0443655014
GSE28863_A4Down-0.1986886696
GSE48662Down-0.4739114872

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

3,5-DiiodotyrosineDB03374 EXPT03137
HYDROXYFASUDILDB04707 -
(1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINEDB06959 -
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINEDB07107 -
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINEDB07204 -
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINEDB07583 -
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDB07854 -
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDB07855 -
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINEDB07856 -
(2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDB07857 -
(2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDB07858 -
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDB07859 -
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINEDB07860 -
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINEDB07876 -
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDB07947 -
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDEDB07995 -
1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINEDB07996 -
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDEDB07997 -
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDB08070 -
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDB08073 -
3-pyridin-4-yl-1H-indazoleDB08113 -
5-benzyl-1,3-thiazol-2-amineDB08114 -
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDB08148 -
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDB08149 -
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminiumDB08150 -
5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINEDB08162 -
MYRISTIC ACIDDB08231 -
(2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINEDB08568 -
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLEDB08569 -
(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDEDB08756 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT006214ChIP-seq//Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22473996
hsa-miR-26b-5pMIMAT0000083MIRT030340MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.