HCSGD entry for MFN1
1. General information
| Official gene symbol | MFN1 |
|---|---|
| Entrez ID | 55669 |
| Gene full name | mitofusin 1 |
| Other gene symbols | hfzo1 hfzo2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005741 | Mitochondrial outer membrane | IEA | cellular_component |
| GO:0008053 | Mitochondrial fusion | IDA IEA IMP | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3050626496 | 0.3785298583 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1035113606 |
| GSE13712_SHEAR | Up | 0.0456682552 |
| GSE13712_STATIC | Up | 0.1118262684 |
| GSE19018 | Up | 0.1137821859 |
| GSE19899_A1 | Up | 0.3433531755 |
| GSE19899_A2 | Up | 0.0731384092 |
| PubMed_21979375_A1 | Up | 0.8266869279 |
| PubMed_21979375_A2 | Up | 0.0363265040 |
| GSE35957 | Down | -0.0371984723 |
| GSE36640 | Up | 0.0786640225 |
| GSE54402 | Up | 0.2787068843 |
| GSE9593 | Down | -0.2269648206 |
| GSE43922 | Up | 0.0007771642 |
| GSE24585 | Up | 0.0228079520 |
| GSE37065 | Up | 0.1176202532 |
| GSE28863_A1 | Down | -0.1213906147 |
| GSE28863_A2 | Up | 0.3222543635 |
| GSE28863_A3 | Down | -1.1666606552 |
| GSE28863_A4 | Down | -0.1795757370 |
| GSE48662 | Down | -0.2410837183 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 28018212 | These changes in morphology were related to slightly levels increases in mitochondrial fusion proteins, Mitofusion 1 (MFN1), and Dynamin-related GTPase (OPA1) |
| 20103533 | Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1 |
| 20103533 | Introduction of Mfn1(T109A), a GTPase-deficient mutant form of Mfn1, into MARCH5-RNAi cells not only disrupted mitochondrial elongation, but also abolished the increase in SA-beta-Gal activity |
Entries Per Page
Displaying Page of
