HCSGD entry for MFN1


1. General information

Official gene symbolMFN1
Entrez ID55669
Gene full namemitofusin 1
Other gene symbolshfzo1 hfzo2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0008053Mitochondrial fusionIDA IEA IMPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30506264960.37852985830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1035113606
GSE13712_SHEARUp0.0456682552
GSE13712_STATICUp0.1118262684
GSE19018Up0.1137821859
GSE19899_A1Up0.3433531755
GSE19899_A2Up0.0731384092
PubMed_21979375_A1Up0.8266869279
PubMed_21979375_A2Up0.0363265040
GSE35957Down-0.0371984723
GSE36640Up0.0786640225
GSE54402Up0.2787068843
GSE9593Down-0.2269648206
GSE43922Up0.0007771642
GSE24585Up0.0228079520
GSE37065Up0.1176202532
GSE28863_A1Down-0.1213906147
GSE28863_A2Up0.3222543635
GSE28863_A3Down-1.1666606552
GSE28863_A4Down-0.1795757370
GSE48662Down-0.2410837183

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

28018212These changes in morphology were related to slightly levels increases in mitochondrial fusion proteins, Mitofusion 1 (MFN1), and Dynamin-related GTPase (OPA1)
20103533Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1
20103533Introduction of Mfn1(T109A), a GTPase-deficient mutant form of Mfn1, into MARCH5-RNAi cells not only disrupted mitochondrial elongation, but also abolished the increase in SA-beta-Gal activity
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