HCSGD entry for LGR4

1. General information

Official gene symbolLGR4
Entrez ID55366
Gene full nameleucine-rich repeat containing G protein-coupled receptor 4
Other gene symbolsGPR48
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationISSbiological_process
GO:0004888Transmembrane signaling receptor activityIDAmolecular_function
GO:0004930G-protein coupled receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007283SpermatogenesisISSbiological_process
GO:0030282Bone mineralizationISSbiological_process
GO:0030539Male genitalia developmentIEAbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayISSbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046849Bone remodelingISSbiological_process
GO:0050673Epithelial cell proliferationIEAbiological_process
GO:0050710Negative regulation of cytokine secretionISSbiological_process
GO:0061290Canonical Wnt signaling pathway involved in metanephric kidney developmentIEAbiological_process
GO:0072202Cell differentiation involved in metanephros developmentIEAbiological_process
GO:0072224Metanephric glomerulus developmentIEAbiological_process
GO:0072282Metanephric nephron tubule morphogenesisIEAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90715279810.04435637320.99999024730.3963014596

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1118528753
GSE13712_SHEARDown-0.7839786667
GSE13712_STATICDown-0.1881845517
GSE19018Up0.1144447017
GSE19899_A1Down-0.2192547262
GSE19899_A2Down-0.0546101620
PubMed_21979375_A1Down-0.1918122294
PubMed_21979375_A2Down-0.2198397451
GSE35957Down-0.1822887025
GSE36640Up0.8297604810
GSE54402Down-0.5663503599
GSE9593Up0.1714478896
GSE43922Down-0.1868662406
GSE24585Down-0.0995719052
GSE37065Up0.3114742874
GSE28863_A1Up0.2382657585
GSE28863_A2Down-0.1528847879
GSE28863_A3Down-0.1397510488
GSE28863_A4Up0.0473777198
GSE48662Down-0.9605207205

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021855MicroarrayFunctional MTI (Weak)17612493
hsa-miR-196a-5pMIMAT0000226MIRT026058SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027834MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.