HCSGD entry for LGR4

1. General information

Official gene symbolLGR4
Entrez ID55366
Gene full nameleucine-rich repeat containing G protein-coupled receptor 4
Other gene symbolsGPR48
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationISSbiological_process
GO:0004888Transmembrane signaling receptor activityIDAmolecular_function
GO:0004930G-protein coupled receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007283SpermatogenesisISSbiological_process
GO:0030282Bone mineralizationISSbiological_process
GO:0030539Male genitalia developmentIEAbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayISSbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046849Bone remodelingISSbiological_process
GO:0050673Epithelial cell proliferationIEAbiological_process
GO:0050710Negative regulation of cytokine secretionISSbiological_process
GO:0061290Canonical Wnt signaling pathway involved in metanephric kidney developmentIEAbiological_process
GO:0072202Cell differentiation involved in metanephros developmentIEAbiological_process
GO:0072224Metanephric glomerulus developmentIEAbiological_process
GO:0072282Metanephric nephron tubule morphogenesisIEAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90715279810.04435637320.99999024730.3963014596

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1118528753
GSE13712_SHEARDown-0.7839786667
GSE13712_STATICDown-0.1881845517
GSE19018Up0.1144447017
GSE19899_A1Down-0.2192547262
GSE19899_A2Down-0.0546101620
PubMed_21979375_A1Down-0.1918122294
PubMed_21979375_A2Down-0.2198397451
GSE35957Down-0.1822887025
GSE36640Up0.8297604810
GSE54402Down-0.5663503599
GSE9593Up0.1714478896
GSE43922Down-0.1868662406
GSE24585Down-0.0995719052
GSE37065Up0.3114742874
GSE28863_A1Up0.2382657585
GSE28863_A2Down-0.1528847879
GSE28863_A3Down-0.1397510488
GSE28863_A4Up0.0473777198
GSE48662Down-0.9605207205

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021855MicroarrayFunctional MTI (Weak)17612493
hsa-miR-196a-5pMIMAT0000226MIRT026058SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027834MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.