HCSGD entry for PPP3CB

1. General information

Official gene symbolPPP3CB
Entrez ID5532
Gene full nameprotein phosphatase 3, catalytic subunit, beta isozyme
Other gene symbolsCALNA2 CALNB CNA2 PP2Bbeta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001915Negative regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0004721Phosphoprotein phosphatase activityIEAmolecular_function
GO:0004722Protein serine/threonine phosphatase activityNASmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIDA NASmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneISScellular_component
GO:0005955Calcineurin complexIDAcellular_component
GO:0006468Protein phosphorylationISSbiological_process
GO:0006470Protein dephosphorylationISSbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007612LearningTASbiological_process
GO:0007613MemoryTASbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0016311DephosphorylationTASbiological_process
GO:0017156Calcium ion-dependent exocytosisISSbiological_process
GO:0019899Enzyme bindingIDAmolecular_function
GO:0030217T cell differentiationIEAbiological_process
GO:0030346Protein phosphatase 2B bindingIDAmolecular_function
GO:0033192Calmodulin-dependent protein phosphatase activityISS TASmolecular_function
GO:0034097Response to cytokineIEAbiological_process
GO:0035176Social behaviorIEPbiological_process
GO:0035690Cellular response to drugIDAbiological_process
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042098T cell proliferationNASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0046983Protein dimerization activityIPImolecular_function
GO:0048167Regulation of synaptic plasticityTASbiological_process
GO:0048675Axon extensionTASbiological_process
GO:0050796Regulation of insulin secretionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06362007900.89599649710.54403641981.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1332107461
GSE13712_SHEARDown-0.4076212155
GSE13712_STATICUp0.0588462652
GSE19018Up0.2726277390
GSE19899_A1Up0.4882715929
GSE19899_A2Up0.4365718469
PubMed_21979375_A1Up1.1154546789
PubMed_21979375_A2Up0.4861618348
GSE35957Up0.1232188946
GSE36640Down-0.1753665152
GSE54402Up0.5783265625
GSE9593Up0.0178630404
GSE43922Up0.1128095099
GSE24585Up0.0705161252
GSE37065Down-0.2493946095
GSE28863_A1Up0.6384608224
GSE28863_A2Up0.2605323937
GSE28863_A3Down-0.1430339434
GSE28863_A4Down-0.0740123600
GSE48662Down-0.2325604700

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10b-5pMIMAT0000254MIRT047460CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.