HCSGD entry for USP47
1. General information
| Official gene symbol | USP47 |
|---|---|
| Entrez ID | 55031 |
| Gene full name | ubiquitin specific peptidase 47 |
| Other gene symbols | TRFP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004221 | Ubiquitin thiolesterase activity | IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006284 | Base-excision repair | IMP | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0010972 | Negative regulation of G2/M transition of mitotic cell cycle | IMP | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | cellular_component |
| GO:0030307 | Positive regulation of cell growth | IMP | biological_process |
| GO:0034644 | Cellular response to UV | ISS | biological_process |
| GO:0035520 | Monoubiquitinated protein deubiquitination | IDA | biological_process |
| GO:0042493 | Response to drug | IMP | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0071987 | WD40-repeat domain binding | IPI | molecular_function |
| GO:1902230 | Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3493859808 | 0.2672050834 | 0.9999902473 | 0.9890435137 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0519983256 |
| GSE13712_SHEAR | Down | -0.0420717319 |
| GSE13712_STATIC | Up | 0.0091815352 |
| GSE19018 | Up | 0.2364157131 |
| GSE19899_A1 | Down | -0.2452701885 |
| GSE19899_A2 | Down | -0.5363000789 |
| PubMed_21979375_A1 | Down | -0.6667269961 |
| PubMed_21979375_A2 | Up | 0.0817708083 |
| GSE35957 | Up | 0.2046089522 |
| GSE36640 | Up | 0.1127659379 |
| GSE54402 | Down | -0.6181229049 |
| GSE9593 | Up | 0.2526024362 |
| GSE43922 | Down | -0.0225583276 |
| GSE24585 | Up | 0.3610144831 |
| GSE37065 | Up | 0.0110511716 |
| GSE28863_A1 | Up | 0.5672381480 |
| GSE28863_A2 | Up | 0.8328565838 |
| GSE28863_A3 | Down | -0.6111590822 |
| GSE28863_A4 | Down | -0.0552895182 |
| GSE48662 | Down | -0.0239617486 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022888 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025520 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030994 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
