HCSGD entry for PPM1A
1. General information
| Official gene symbol | PPM1A |
|---|---|
| Entrez ID | 5494 |
| Gene full name | protein phosphatase, Mg2+/Mn2+ dependent, 1A |
| Other gene symbols | PP2C-ALPHA PP2CA PP2Calpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004722 | Protein serine/threonine phosphatase activity | IDA IEA TAS | molecular_function |
| GO:0004871 | Signal transducer activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA ISS TAS | cellular_component |
| GO:0005891 | Voltage-gated calcium channel complex | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006470 | Protein dephosphorylation | IEA IMP | biological_process |
| GO:0006499 | N-terminal protein myristoylation | IEA ISS | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IEA | molecular_function |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010991 | Negative regulation of SMAD protein complex assembly | IDA | biological_process |
| GO:0016020 | Membrane | ISS | cellular_component |
| GO:0016055 | Wnt signaling pathway | IDA | biological_process |
| GO:0016311 | Dephosphorylation | IDA | biological_process |
| GO:0030145 | Manganese ion binding | IEA | molecular_function |
| GO:0030177 | Positive regulation of Wnt signaling pathway | IDA | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0033192 | Calmodulin-dependent protein phosphatase activity | IDA | molecular_function |
| GO:0035970 | Peptidyl-threonine dephosphorylation | IDA | biological_process |
| GO:0042347 | Negative regulation of NF-kappaB import into nucleus | IMP | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0043124 | Negative regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070412 | R-SMAD binding | IPI | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5215405798 | 0.5684967592 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0216173974 |
| GSE13712_SHEAR | Down | -0.0810712196 |
| GSE13712_STATIC | Down | -0.1331189348 |
| GSE19018 | Up | 0.4184273523 |
| GSE19899_A1 | Up | 0.1238081304 |
| GSE19899_A2 | Down | -0.1120611842 |
| PubMed_21979375_A1 | Down | -0.1238991609 |
| PubMed_21979375_A2 | Down | -0.0730210823 |
| GSE35957 | Up | 0.2281613055 |
| GSE36640 | Up | 0.0423204214 |
| GSE54402 | Down | -0.0661889883 |
| GSE9593 | Up | 0.1548060061 |
| GSE43922 | Up | 0.0337659808 |
| GSE24585 | Down | -0.1075591405 |
| GSE37065 | Down | -0.0286521902 |
| GSE28863_A1 | Up | 0.0969043758 |
| GSE28863_A2 | Up | 0.1242243193 |
| GSE28863_A3 | Down | -0.5798380203 |
| GSE28863_A4 | Up | 0.0925607590 |
| GSE48662 | Up | 0.0560714984 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-377-3p | MIMAT0000730 | MIRT000990 | Luciferase reporter assay//Western blot | Non-Functional MTI | 18716028 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026486 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-484 | MIMAT0002174 | MIRT041899 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046263 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048669 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21205865 | Here, we show that the mechanism by which PML induces a permanent cell cycle exit and activates p53 and senescence involves a recruitment of E2F transcription factors bound to their promoters and the retinoblastoma (Rb) proteins to PML nuclear bodies enriched in heterochromatin proteins and protein phosphatase 1alpha |
Entries Per Page
Displaying Page of
