HCSGD entry for PPM1A

1. General information

Official gene symbolPPM1A
Entrez ID5494
Gene full nameprotein phosphatase, Mg2+/Mn2+ dependent, 1A
Other gene symbolsPP2C-ALPHA PP2CA PP2Calpha
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0003824Catalytic activityIEAmolecular_function
GO:0004722Protein serine/threonine phosphatase activityIDA IEA TASmolecular_function
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolIEA ISS TAScellular_component
GO:0005891Voltage-gated calcium channel complexIEAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006470Protein dephosphorylationIEA IMPbiological_process
GO:0006499N-terminal protein myristoylationIEA ISSbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010991Negative regulation of SMAD protein complex assemblyIDAbiological_process
GO:0016020MembraneISScellular_component
GO:0016055Wnt signaling pathwayIDAbiological_process
GO:0016311DephosphorylationIDAbiological_process
GO:0030145Manganese ion bindingIEAmolecular_function
GO:0030177Positive regulation of Wnt signaling pathwayIDAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0033192Calmodulin-dependent protein phosphatase activityIDAmolecular_function
GO:0035970Peptidyl-threonine dephosphorylationIDAbiological_process
GO:0042347Negative regulation of NF-kappaB import into nucleusIMPbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0070412R-SMAD bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52154057980.56849675920.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0216173974
GSE13712_SHEARDown-0.0810712196
GSE13712_STATICDown-0.1331189348
GSE19018Up0.4184273523
GSE19899_A1Up0.1238081304
GSE19899_A2Down-0.1120611842
PubMed_21979375_A1Down-0.1238991609
PubMed_21979375_A2Down-0.0730210823
GSE35957Up0.2281613055
GSE36640Up0.0423204214
GSE54402Down-0.0661889883
GSE9593Up0.1548060061
GSE43922Up0.0337659808
GSE24585Down-0.1075591405
GSE37065Down-0.0286521902
GSE28863_A1Up0.0969043758
GSE28863_A2Up0.1242243193
GSE28863_A3Down-0.5798380203
GSE28863_A4Up0.0925607590
GSE48662Up0.0560714984

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-377-3pMIMAT0000730MIRT000990Luciferase reporter assay//Western blotNon-Functional MTI18716028
hsa-miR-192-5pMIMAT0000222MIRT026486MicroarrayFunctional MTI (Weak)19074876
hsa-miR-484MIMAT0002174MIRT041899CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046263CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048669CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21205865Here, we show that the mechanism by which PML induces a permanent cell cycle exit and activates p53 and senescence involves a recruitment of E2F transcription factors bound to their promoters and the retinoblastoma (Rb) proteins to PML nuclear bodies enriched in heterochromatin proteins and protein phosphatase 1alpha
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