HCSGD entry for POLR2B
1. General information
| Official gene symbol | POLR2B |
|---|---|
| Entrez ID | 5431 |
| Gene full name | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa |
| Other gene symbols | POL2RB RPB2 hRPB140 hsRPB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0001055 | RNA polymerase II activity | IBA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005665 | DNA-directed RNA polymerase II, core complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006368 | Transcription elongation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006370 | 7-methylguanosine mRNA capping | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0032549 | Ribonucleoside binding | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050434 | Positive regulation of viral transcription | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8362071730 | 0.3224848562 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2046745350 |
| GSE13712_SHEAR | Down | -0.0483065582 |
| GSE13712_STATIC | Down | -0.0303760614 |
| GSE19018 | Down | -0.1064699100 |
| GSE19899_A1 | Down | -0.0264608174 |
| GSE19899_A2 | Down | -0.1633045084 |
| PubMed_21979375_A1 | Down | -0.0873903967 |
| PubMed_21979375_A2 | Up | 0.0058273966 |
| GSE35957 | Up | 0.0547088536 |
| GSE36640 | Up | 0.5265255525 |
| GSE54402 | Up | 0.0932811922 |
| GSE9593 | Down | -0.1639708103 |
| GSE43922 | Down | -0.0106373099 |
| GSE24585 | Up | 0.0803555136 |
| GSE37065 | Down | -0.0685986903 |
| GSE28863_A1 | Up | 0.0663076439 |
| GSE28863_A2 | Up | 0.1962746113 |
| GSE28863_A3 | Down | -0.6922823002 |
| GSE28863_A4 | Down | -0.1950565272 |
| GSE48662 | Down | -0.3789619887 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023207 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028617 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037880 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040387 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
