HCSGD entry for POLR2B

1. General information

Official gene symbolPOLR2B
Entrez ID5431
Gene full namepolymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Other gene symbolsPOL2RB RPB2 hRPB140 hsRPB2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000398MRNA splicing, via spliceosomeTASbiological_process
GO:0001055RNA polymerase II activityIBAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003899DNA-directed RNA polymerase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005665DNA-directed RNA polymerase II, core complexIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0032549Ribonucleoside bindingIEAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050434Positive regulation of viral transcriptionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83620717300.32248485620.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2046745350
GSE13712_SHEARDown-0.0483065582
GSE13712_STATICDown-0.0303760614
GSE19018Down-0.1064699100
GSE19899_A1Down-0.0264608174
GSE19899_A2Down-0.1633045084
PubMed_21979375_A1Down-0.0873903967
PubMed_21979375_A2Up0.0058273966
GSE35957Up0.0547088536
GSE36640Up0.5265255525
GSE54402Up0.0932811922
GSE9593Down-0.1639708103
GSE43922Down-0.0106373099
GSE24585Up0.0803555136
GSE37065Down-0.0685986903
GSE28863_A1Up0.0663076439
GSE28863_A2Up0.1962746113
GSE28863_A3Down-0.6922823002
GSE28863_A4Down-0.1950565272
GSE48662Down-0.3789619887

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT023207Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-30a-5pMIMAT0000087MIRT028617ProteomicsFunctional MTI (Weak)18668040
hsa-miR-455-3pMIMAT0004784MIRT037880CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040387CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.