HCSGD entry for ERRFI1
1. General information
| Official gene symbol | ERRFI1 |
|---|---|
| Entrez ID | 54206 |
| Gene full name | ERBB receptor feedback inhibitor 1 |
| Other gene symbols | GENE-33 MIG-6 MIG6 RALT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005100 | Rho GTPase activator activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0007175 | Negative regulation of epidermal growth factor-activated receptor activity | IDA ISS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | ISS | cellular_component |
| GO:0031953 | Negative regulation of protein autophosphorylation | IDA | biological_process |
| GO:0032320 | Positive regulation of Ras GTPase activity | TAS | biological_process |
| GO:0032321 | Positive regulation of Rho GTPase activity | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | TAS | biological_process |
| GO:0043589 | Skin morphogenesis | ISS | biological_process |
| GO:0045616 | Regulation of keratinocyte differentiation | ISS | biological_process |
| GO:0048286 | Lung alveolus development | ISS | biological_process |
| GO:0060426 | Lung vasculature development | ISS | biological_process |
| GO:0060428 | Lung epithelium development | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0089074541 | 0.1225229209 | 0.2422002058 | 0.6717196001 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.3577377492 |
| GSE13712_SHEAR | Up | 0.5018491085 |
| GSE13712_STATIC | Down | -0.2091827393 |
| GSE19018 | Down | -0.1515460478 |
| GSE19899_A1 | Up | 0.9188628225 |
| GSE19899_A2 | Up | 0.7195331880 |
| PubMed_21979375_A1 | Up | 2.4228019199 |
| PubMed_21979375_A2 | Up | 1.0305251028 |
| GSE35957 | Down | -0.6483617722 |
| GSE36640 | Down | -0.9478030396 |
| GSE54402 | Up | 0.3398026074 |
| GSE9593 | Up | 0.4904133722 |
| GSE43922 | Up | 1.2163120949 |
| GSE24585 | Up | 0.2092318415 |
| GSE37065 | Down | -0.1159698563 |
| GSE28863_A1 | Up | 0.3351667523 |
| GSE28863_A2 | Up | 0.3258342188 |
| GSE28863_A3 | Down | -1.2657495913 |
| GSE28863_A4 | Up | 0.1058158344 |
| GSE48662 | Up | 0.3604036278 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200c-3p | MIMAT0000617 | MIRT006520 | Luciferase reporter assay | Functional MTI | 19671845 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016297 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038059 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043883 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050678 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-200b-3p | MIMAT0000318 | NA | hsa-miR-200b | 19671845 | |||
| hsa-miR-200c-3p | MIMAT0000617 | NA | hsa-miR-200c | 19671845 | |||
| hsa-miR-429 | MIMAT0001536 | NA | hsa-miR-429 | 19671845 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24815188 | Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation |
| 24815188 | Mitogen-inducible gene-6 (Mig-6) is a cytosolic multiadaptor protein that is best known for its role as a negative feedback regulator of epidermal growth factor receptor (EGFR) mediated signalling |
| 24815188 | Alternative roles of Mig-6 are becoming increasingly recognised |
| 24815188 | Consistently with this, Mig-6 was demonstrated to be involved in a broad spectrum of cellular events including tumour suppression which may include the induction of cellular senescence |
| 24815188 | Here, we investigated the mechanisms of Mig-6 induced premature cell senescence |
| 24815188 | Endogenous Mig-6 is poorly expressed in young fibroblasts, whilst its expression rises in cells presenting with typical features of senescence |
| 24815188 | Overexpression of Mig-6 is sufficient to trigger premature cellular senescence of early passage diploid lung fibroblasts (WI-38) |
| 24815188 | Interestingly, Mig-6 overexpression reduced retinoblastoma protein (pRb) phosphorylation at the inactivating Ser249/Thr252 sites |
| 24815188 | We further show that Mig-6 overexpression reduces B-Raf V600E mediated pRb inactivation and preserves pRb function |
| 23746120 | BACKGROUND INFORMATION: The mitogen-inducible gene-6 (Mig-6) is a non-kinase scaffolding adaptor protein |
| 23746120 | It has been shown that Mig-6 may play important roles in regulating stress response, maintaining homeostasis and functioning as a tumour suppressor |
| 23746120 | RESULTS: Our results showed that Mig-6 is up-regulated during the senescence process |
| 23746120 | Functional analysis indicated that cells over-expressing Mig-6 have reduced DNA synthesis and showed the signs of senescence |
| 23746120 | Knockdown of Mig-6 delayed the initiation of Ras-induced cellular senescence |
| 23746120 | These results suggest that the increase of Mig-6 expression contributes to establishment of cellular senescence |
| 23746120 | Furthermore, our results showed that Mig-6 induction of senescence is related to its inhibition of EGF receptor (EGFR)/Erb B signalling |
| 23746120 | CONCLUSIONS: Mig-6 induces premature senescence via functioning in regulation of cellular senescence in normal diploid fibroblasts |
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