HCSGD entry for ERRFI1

1. General information

Official gene symbolERRFI1
Entrez ID54206
Gene full nameERBB receptor feedback inhibitor 1
Other gene symbolsGENE-33 MIG-6 MIG6 RALT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005100Rho GTPase activator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0006950Response to stressTASbiological_process
GO:0007175Negative regulation of epidermal growth factor-activated receptor activityIDA ISSbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneISScellular_component
GO:0031953Negative regulation of protein autophosphorylationIDAbiological_process
GO:0032320Positive regulation of Ras GTPase activityTASbiological_process
GO:0032321Positive regulation of Rho GTPase activityTASbiological_process
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0043547Positive regulation of GTPase activityTASbiological_process
GO:0043589Skin morphogenesisISSbiological_process
GO:0045616Regulation of keratinocyte differentiationISSbiological_process
GO:0048286Lung alveolus developmentISSbiological_process
GO:0060426Lung vasculature developmentISSbiological_process
GO:0060428Lung epithelium developmentISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00890745410.12252292090.24220020580.6717196001

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-2.3577377492
GSE13712_SHEARUp0.5018491085
GSE13712_STATICDown-0.2091827393
GSE19018Down-0.1515460478
GSE19899_A1Up0.9188628225
GSE19899_A2Up0.7195331880
PubMed_21979375_A1Up2.4228019199
PubMed_21979375_A2Up1.0305251028
GSE35957Down-0.6483617722
GSE36640Down-0.9478030396
GSE54402Up0.3398026074
GSE9593Up0.4904133722
GSE43922Up1.2163120949
GSE24585Up0.2092318415
GSE37065Down-0.1159698563
GSE28863_A1Up0.3351667523
GSE28863_A2Up0.3258342188
GSE28863_A3Down-1.2657495913
GSE28863_A4Up0.1058158344
GSE48662Up0.3604036278

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT006520Luciferase reporter assayFunctional MTI19671845
hsa-miR-193b-3pMIMAT0002819MIRT016297MicroarrayFunctional MTI (Weak)20304954
hsa-miR-423-5pMIMAT0004748MIRT038059CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-3pMIMAT0000732MIRT043883CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050678CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-200b-3pMIMAT0000318NAhsa-miR-200b19671845
hsa-miR-200c-3pMIMAT0000617NAhsa-miR-200c19671845
hsa-miR-429MIMAT0001536NAhsa-miR-42919671845
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24815188Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation
24815188Mitogen-inducible gene-6 (Mig-6) is a cytosolic multiadaptor protein that is best known for its role as a negative feedback regulator of epidermal growth factor receptor (EGFR) mediated signalling
24815188Alternative roles of Mig-6 are becoming increasingly recognised
24815188Consistently with this, Mig-6 was demonstrated to be involved in a broad spectrum of cellular events including tumour suppression which may include the induction of cellular senescence
24815188Here, we investigated the mechanisms of Mig-6 induced premature cell senescence
24815188Endogenous Mig-6 is poorly expressed in young fibroblasts, whilst its expression rises in cells presenting with typical features of senescence
24815188Overexpression of Mig-6 is sufficient to trigger premature cellular senescence of early passage diploid lung fibroblasts (WI-38)
24815188Interestingly, Mig-6 overexpression reduced retinoblastoma protein (pRb) phosphorylation at the inactivating Ser249/Thr252 sites
24815188We further show that Mig-6 overexpression reduces B-Raf V600E mediated pRb inactivation and preserves pRb function
23746120BACKGROUND INFORMATION: The mitogen-inducible gene-6 (Mig-6) is a non-kinase scaffolding adaptor protein
23746120It has been shown that Mig-6 may play important roles in regulating stress response, maintaining homeostasis and functioning as a tumour suppressor
23746120RESULTS: Our results showed that Mig-6 is up-regulated during the senescence process
23746120Functional analysis indicated that cells over-expressing Mig-6 have reduced DNA synthesis and showed the signs of senescence
23746120Knockdown of Mig-6 delayed the initiation of Ras-induced cellular senescence
23746120These results suggest that the increase of Mig-6 expression contributes to establishment of cellular senescence
23746120Furthermore, our results showed that Mig-6 induction of senescence is related to its inhibition of EGF receptor (EGFR)/Erb B signalling
23746120CONCLUSIONS: Mig-6 induces premature senescence via functioning in regulation of cellular senescence in normal diploid fibroblasts
Entries Per Page
Displaying Page of