HCSGD entry for SEPT4

1. General information

Official gene symbolSEPT4
Entrez ID5414
Gene full nameseptin 4
Other gene symbolsARTS BRADEION CE5B3 H5 MART PNUTL2 SEP4 hCDCREL-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000910CytokinesisTASbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0005198Structural molecule activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005739MitochondrionNAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006184GTP catabolic processTASbiological_process
GO:0006915Apoptotic processNASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0030382Sperm mitochondrion organizationIEAbiological_process
GO:0031105Septin complexIEAcellular_component
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0031514Motile ciliumIEAcellular_component
GO:0042981Regulation of apoptotic processNASbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0048240Sperm capacitationIEAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87186521410.43898740930.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0050586073
GSE13712_SHEARDown-0.1001083046
GSE13712_STATICDown-0.2038756700
GSE19018Up0.0468413013
GSE19899_A1Down-0.0309087085
GSE19899_A2Up0.0148138001
PubMed_21979375_A1Up0.0392067163
PubMed_21979375_A2Up0.0178690129
GSE35957Up0.1040854660
GSE36640Down-0.1174004681
GSE54402Down-0.0679205877
GSE9593Down-0.1350176194
GSE43922Up0.0274822011
GSE24585Up0.2562362560
GSE37065Down-0.2663415095
GSE28863_A1Down-0.2330489476
GSE28863_A2Down-0.3331865349
GSE28863_A3Up0.1888177595
GSE28863_A4Up0.2090556792
GSE48662Up0.0986733989

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017716MicroarrayFunctional MTI (Weak)18185580
hsa-let-7b-5pMIMAT0000063MIRT032353ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.