HCSGD entry for TLR9

1. General information

Official gene symbolTLR9
Entrez ID54106
Gene full nametoll-like receptor 9
Other gene symbolsCD289
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002237Response to molecule of bacterial originTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEAbiological_process
GO:0004888Transmembrane signaling receptor activityIEAmolecular_function
GO:0005149Interleukin-1 receptor bindingIPImolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeISScellular_component
GO:0005768EndosomeISScellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0030277Maintenance of gastrointestinal epitheliumISSbiological_process
GO:0032009Early phagosomeISScellular_component
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032715Negative regulation of interleukin-6 productionISSbiological_process
GO:0032717Negative regulation of interleukin-8 productionIDAbiological_process
GO:0032722Positive regulation of chemokine productionIDAbiological_process
GO:0032728Positive regulation of interferon-beta productionISSbiological_process
GO:0032733Positive regulation of interleukin-10 productionISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032741Positive regulation of interleukin-18 productionISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionISSbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0034123Positive regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0035197SiRNA bindingIMPmolecular_function
GO:0036020Endolysosome membraneTAScellular_component
GO:0042346Positive regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0042742Defense response to bacteriumNASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043507Positive regulation of JUN kinase activityIDAbiological_process
GO:0045078Positive regulation of interferon-gamma biosynthetic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045356Positive regulation of interferon-alpha biosynthetic processIDAbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046330Positive regulation of JNK cascadeICbiological_process
GO:0050707Regulation of cytokine secretionIEAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051770Positive regulation of nitric-oxide synthase biosynthetic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19888896700.88858634170.86147360541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1120014797
GSE13712_SHEARDown-0.1188573520
GSE13712_STATICUp0.1466334266
GSE19018Up0.1107272057
GSE19899_A1Down-0.0051137969
GSE19899_A2Up0.2836190153
PubMed_21979375_A1Up0.0238037635
PubMed_21979375_A2Down-0.0569583297
GSE35957Up0.2809086214
GSE36640Up0.0030708512
GSE54402Up0.0594885554
GSE9593Down-0.1213851683
GSE43922Up0.2386269801
GSE24585Up0.0267740508
GSE37065Down-0.0641852226
GSE28863_A1Up0.2312889015
GSE28863_A2Up0.3721308472
GSE28863_A3Up0.2630427956
GSE28863_A4Up0.0974368680
GSE48662Up0.0498632158

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ChloroquineDB00608 APRD00468
ISS-1018DB05463 -
SCV-07DB05475 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.