HCSGD entry for TLR9

1. General information

Official gene symbolTLR9
Entrez ID54106
Gene full nametoll-like receptor 9
Other gene symbolsCD289
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002237Response to molecule of bacterial originTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEAbiological_process
GO:0004888Transmembrane signaling receptor activityIEAmolecular_function
GO:0005149Interleukin-1 receptor bindingIPImolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeISScellular_component
GO:0005768EndosomeISScellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0030277Maintenance of gastrointestinal epitheliumISSbiological_process
GO:0032009Early phagosomeISScellular_component
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032715Negative regulation of interleukin-6 productionISSbiological_process
GO:0032717Negative regulation of interleukin-8 productionIDAbiological_process
GO:0032722Positive regulation of chemokine productionIDAbiological_process
GO:0032728Positive regulation of interferon-beta productionISSbiological_process
GO:0032733Positive regulation of interleukin-10 productionISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032741Positive regulation of interleukin-18 productionISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionISSbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0034123Positive regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0035197SiRNA bindingIMPmolecular_function
GO:0036020Endolysosome membraneTAScellular_component
GO:0042346Positive regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0042742Defense response to bacteriumNASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043507Positive regulation of JUN kinase activityIDAbiological_process
GO:0045078Positive regulation of interferon-gamma biosynthetic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045356Positive regulation of interferon-alpha biosynthetic processIDAbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046330Positive regulation of JNK cascadeICbiological_process
GO:0050707Regulation of cytokine secretionIEAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051770Positive regulation of nitric-oxide synthase biosynthetic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19888896700.88858634170.86147360541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1120014797
GSE13712_SHEARDown-0.1188573520
GSE13712_STATICUp0.1466334266
GSE19018Up0.1107272057
GSE19899_A1Down-0.0051137969
GSE19899_A2Up0.2836190153
PubMed_21979375_A1Up0.0238037635
PubMed_21979375_A2Down-0.0569583297
GSE35957Up0.2809086214
GSE36640Up0.0030708512
GSE54402Up0.0594885554
GSE9593Down-0.1213851683
GSE43922Up0.2386269801
GSE24585Up0.0267740508
GSE37065Down-0.0641852226
GSE28863_A1Up0.2312889015
GSE28863_A2Up0.3721308472
GSE28863_A3Up0.2630427956
GSE28863_A4Up0.0974368680
GSE48662Up0.0498632158

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ChloroquineDB00608 APRD00468
ISS-1018DB05463 -
SCV-07DB05475 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.