HCSGD entry for PMAIP1
1. General information
| Official gene symbol | PMAIP1 |
|---|---|
| Entrez ID | 5366 |
| Gene full name | phorbol-12-myristate-13-acetate-induced protein 1 |
| Other gene symbols | APR NOXA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001836 | Release of cytochrome c from mitochondria | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006915 | Apoptotic process | IMP TAS | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0009411 | Response to UV | IEA | biological_process |
| GO:0010165 | Response to X-ray | IEA | biological_process |
| GO:0010498 | Proteasomal protein catabolic process | IDA | biological_process |
| GO:0010907 | Positive regulation of glucose metabolic process | IDA | biological_process |
| GO:0010917 | Negative regulation of mitochondrial membrane potential | ISS | biological_process |
| GO:0032461 | Positive regulation of protein oligomerization | IDA | biological_process |
| GO:0042149 | Cellular response to glucose starvation | IMP | biological_process |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IEA | biological_process |
| GO:0043029 | T cell homeostasis | ISS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA IMP | biological_process |
| GO:0043280 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0043331 | Response to dsRNA | IDA | biological_process |
| GO:0043517 | Positive regulation of DNA damage response, signal transduction by p53 class mediator | IMP | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0046902 | Regulation of mitochondrial membrane permeability | IDA | biological_process |
| GO:0048147 | Negative regulation of fibroblast proliferation | IEA | biological_process |
| GO:0051607 | Defense response to virus | IDA | biological_process |
| GO:0071456 | Cellular response to hypoxia | IEP | biological_process |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IMP | biological_process |
| GO:0072593 | Reactive oxygen species metabolic process | IDA | biological_process |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | IDA IMP | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | IDA TAS | biological_process |
| GO:1900740 | Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | biological_process |
| GO:1902043 | Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | IDA | biological_process |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | IDA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0018610881 | 0.3390750959 | 0.1149590164 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6035891064 |
| GSE13712_SHEAR | Up | 1.0521321088 |
| GSE13712_STATIC | Up | 0.2913519341 |
| GSE19018 | Up | 0.0797530088 |
| GSE19899_A1 | Up | 0.7838152379 |
| GSE19899_A2 | Up | 0.7793421555 |
| PubMed_21979375_A1 | Up | 1.6849766467 |
| PubMed_21979375_A2 | Up | 0.9750059197 |
| GSE35957 | Down | -2.7240445878 |
| GSE36640 | Up | 0.6803117271 |
| GSE54402 | Up | 0.2356172753 |
| GSE9593 | Up | 1.1612503659 |
| GSE43922 | Up | 0.6232473451 |
| GSE24585 | Down | -0.2264317383 |
| GSE37065 | Up | 0.8969462231 |
| GSE28863_A1 | Down | -0.4454082724 |
| GSE28863_A2 | Up | 0.8116164303 |
| GSE28863_A3 | Down | -0.6974185539 |
| GSE28863_A4 | Up | 0.4341435998 |
| GSE48662 | Down | -0.6854949788 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200c-3p | MIMAT0000617 | MIRT007018 | Luciferase reporter assay | Functional MTI | 22615771 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021168 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027675 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029656 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7f-2-3p | MIMAT0004487 | MIRT038989 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040967 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041571 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043467 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045943 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24853380 | At the molecular level, MLN4924 inactivated Cullin-RING E3 ligases, led to accumulation of tumor-suppressive Cullin-RING E3 ligase substrates and induced phorbol-12-myristate-13-acetate-induced protein 1 (NOXA)-dependent apoptosis or cellular senescence |
| 23811199 | The phosphorylation of p53 and histone H2Ax and the induction of the two proapoptotic genes Bax and Noxa were evident in SOD1-deficient MEFs and more enhanced under normoxic culture than under hypoxic culture |
| 23612976 | However, we also uncover a regulatory pathway whereby suppression of p53 Ser(15) phosphorylation is associated with enhanced phosphorylation at Ser(46), increased p53 protein levels, and induction of Noxa expression |
| 21110788 | Bach1-deficient MEFs bypassed the senescence state when the expression of a subset of p53 target genes, including p21, Pai1, Noxa, and Perp, was simultaneously reduced by using RNAi |
| 20703098 | This network functions mainly through transactivation of different downstream targets, including cell cycle inhibitor p21, which is required for short-term cell cycle arrest or long-term cellular senescence, or proapoptotic genes such as p53 upregulated modulator of apoptosis (PUMA) and Noxa |
| 20703098 | Mutant MEFs show an induction of p53 and p21 after UVR, while wild-type MEFs additionally induce PUMA and Noxa |
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