HCSGD entry for PMAIP1

1. General information

Official gene symbolPMAIP1
Entrez ID5366
Gene full namephorbol-12-myristate-13-acetate-induced protein 1
Other gene symbolsAPR NOXA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001836Release of cytochrome c from mitochondriaIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005741Mitochondrial outer membraneTAScellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006915Apoptotic processIMP TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0009411Response to UVIEAbiological_process
GO:0010165Response to X-rayIEAbiological_process
GO:0010498Proteasomal protein catabolic processIDAbiological_process
GO:0010907Positive regulation of glucose metabolic processIDAbiological_process
GO:0010917Negative regulation of mitochondrial membrane potentialISSbiological_process
GO:0032461Positive regulation of protein oligomerizationIDAbiological_process
GO:0042149Cellular response to glucose starvationIMPbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIEAbiological_process
GO:0043029T cell homeostasisISSbiological_process
GO:0043065Positive regulation of apoptotic processIDA IMPbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043331Response to dsRNAIDAbiological_process
GO:0043517Positive regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0046902Regulation of mitochondrial membrane permeabilityIDAbiological_process
GO:0048147Negative regulation of fibroblast proliferationIEAbiological_process
GO:0051607Defense response to virusIDAbiological_process
GO:0071456Cellular response to hypoxiaIEPbiological_process
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIMPbiological_process
GO:0072593Reactive oxygen species metabolic processIDAbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIDA IMPbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayIDA TASbiological_process
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
GO:1902043Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIDAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIDA TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00186108810.33907509590.11495901641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6035891064
GSE13712_SHEARUp1.0521321088
GSE13712_STATICUp0.2913519341
GSE19018Up0.0797530088
GSE19899_A1Up0.7838152379
GSE19899_A2Up0.7793421555
PubMed_21979375_A1Up1.6849766467
PubMed_21979375_A2Up0.9750059197
GSE35957Down-2.7240445878
GSE36640Up0.6803117271
GSE54402Up0.2356172753
GSE9593Up1.1612503659
GSE43922Up0.6232473451
GSE24585Down-0.2264317383
GSE37065Up0.8969462231
GSE28863_A1Down-0.4454082724
GSE28863_A2Up0.8116164303
GSE28863_A3Down-0.6974185539
GSE28863_A4Up0.4341435998
GSE48662Down-0.6854949788

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT007018Luciferase reporter assayFunctional MTI22615771
hsa-miR-186-5pMIMAT0000456MIRT021168SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027675MicroarrayFunctional MTI (Weak)19088304
hsa-miR-26b-5pMIMAT0000083MIRT029656SequencingFunctional MTI (Weak)20371350
hsa-let-7f-2-3pMIMAT0004487MIRT038989CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040967CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041571CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043467CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045943CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24853380At the molecular level, MLN4924 inactivated Cullin-RING E3 ligases, led to accumulation of tumor-suppressive Cullin-RING E3 ligase substrates and induced phorbol-12-myristate-13-acetate-induced protein 1 (NOXA)-dependent apoptosis or cellular senescence
23811199The phosphorylation of p53 and histone H2Ax and the induction of the two proapoptotic genes Bax and Noxa were evident in SOD1-deficient MEFs and more enhanced under normoxic culture than under hypoxic culture
23612976However, we also uncover a regulatory pathway whereby suppression of p53 Ser(15) phosphorylation is associated with enhanced phosphorylation at Ser(46), increased p53 protein levels, and induction of Noxa expression
21110788Bach1-deficient MEFs bypassed the senescence state when the expression of a subset of p53 target genes, including p21, Pai1, Noxa, and Perp, was simultaneously reduced by using RNAi
20703098This network functions mainly through transactivation of different downstream targets, including cell cycle inhibitor p21, which is required for short-term cell cycle arrest or long-term cellular senescence, or proapoptotic genes such as p53 upregulated modulator of apoptosis (PUMA) and Noxa
20703098Mutant MEFs show an induction of p53 and p21 after UVR, while wild-type MEFs additionally induce PUMA and Noxa
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