HCSGD entry for PLXNB1

1. General information

Official gene symbolPLXNB1
Entrez ID5364
Gene full nameplexin B1
Other gene symbolsPLEXIN-B1 PLXN5 SEP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002116Semaphorin receptor complexIDA TAScellular_component
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005622IntracellularIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDA NAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008360Regulation of cell shapeIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEA ISSbiological_process
GO:0016477Cell migrationNASbiological_process
GO:0017154Semaphorin receptor activityIDA TASmolecular_function
GO:0030215Semaphorin receptor bindingTASmolecular_function
GO:0032321Positive regulation of Rho GTPase activityIEA ISSbiological_process
GO:0032794GTPase activating protein bindingIEA ISSmolecular_function
GO:0033689Negative regulation of osteoblast proliferationIEA ISSbiological_process
GO:0035556Intracellular signal transductionNASbiological_process
GO:0043931Ossification involved in bone maturationIEA ISSbiological_process
GO:0048812Neuron projection morphogenesisIEA ISSbiological_process
GO:0050772Positive regulation of axonogenesisIEAbiological_process
GO:0051493Regulation of cytoskeleton organizationIDAbiological_process
GO:0071526Semaphorin-plexin signaling pathwayIDAbiological_process
GO:1900220Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30017657380.50887247450.99882756311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1121368513
GSE13712_SHEARDown-0.9285436028
GSE13712_STATICDown-0.2129109660
GSE19018Up0.0433755153
GSE19899_A1Down-0.1003785443
GSE19899_A2Down-0.1423527065
PubMed_21979375_A1Up0.4441784754
PubMed_21979375_A2Up0.0388690020
GSE35957Up0.0352417213
GSE36640Up0.3429886067
GSE54402Down-0.2755158526
GSE9593Down-0.2374459722
GSE43922Up0.0523097454
GSE24585Up0.2376049423
GSE37065Up0.2730034140
GSE28863_A1Up0.0393794306
GSE28863_A2Up0.0565133569
GSE28863_A3Up0.1349736535
GSE28863_A4Down-0.0966435848
GSE48662Up0.6976406863

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-214-3pMIMAT0000271MIRT005765GFP reporter assay//Immunohistochemistry//qRT-PCR//Western blotFunctional MTI21216304
hsa-miR-214-3pMIMAT0000271MIRT005765Microarray;OtherFunctional MTI (Weak)19859982
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.