HCSGD entry for PLXNB1

1. General information

Official gene symbolPLXNB1
Entrez ID5364
Gene full nameplexin B1
Other gene symbolsPLEXIN-B1 PLXN5 SEP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002116Semaphorin receptor complexIDA TAScellular_component
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005622IntracellularIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDA NAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008360Regulation of cell shapeIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEA ISSbiological_process
GO:0016477Cell migrationNASbiological_process
GO:0017154Semaphorin receptor activityIDA TASmolecular_function
GO:0030215Semaphorin receptor bindingTASmolecular_function
GO:0032321Positive regulation of Rho GTPase activityIEA ISSbiological_process
GO:0032794GTPase activating protein bindingIEA ISSmolecular_function
GO:0033689Negative regulation of osteoblast proliferationIEA ISSbiological_process
GO:0035556Intracellular signal transductionNASbiological_process
GO:0043931Ossification involved in bone maturationIEA ISSbiological_process
GO:0048812Neuron projection morphogenesisIEA ISSbiological_process
GO:0050772Positive regulation of axonogenesisIEAbiological_process
GO:0051493Regulation of cytoskeleton organizationIDAbiological_process
GO:0071526Semaphorin-plexin signaling pathwayIDAbiological_process
GO:1900220Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30017657380.50887247450.99882756311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1121368513
GSE13712_SHEARDown-0.9285436028
GSE13712_STATICDown-0.2129109660
GSE19018Up0.0433755153
GSE19899_A1Down-0.1003785443
GSE19899_A2Down-0.1423527065
PubMed_21979375_A1Up0.4441784754
PubMed_21979375_A2Up0.0388690020
GSE35957Up0.0352417213
GSE36640Up0.3429886067
GSE54402Down-0.2755158526
GSE9593Down-0.2374459722
GSE43922Up0.0523097454
GSE24585Up0.2376049423
GSE37065Up0.2730034140
GSE28863_A1Up0.0393794306
GSE28863_A2Up0.0565133569
GSE28863_A3Up0.1349736535
GSE28863_A4Down-0.0966435848
GSE48662Up0.6976406863

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-214-3pMIMAT0000271MIRT005765GFP reporter assay//Immunohistochemistry//qRT-PCR//Western blotFunctional MTI21216304
hsa-miR-214-3pMIMAT0000271MIRT005765Microarray;OtherFunctional MTI (Weak)19859982
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.