HCSGD entry for PKP1

1. General information

Official gene symbolPKP1
Entrez ID5317
Gene full nameplakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
Other gene symbolsB6P
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005521Lamin bindingIDAmolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005882Intermediate filamentTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007155Cell adhesionNASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0019215Intermediate filament bindingNASmolecular_function
GO:0030057DesmosomeNAScellular_component
GO:0030280Structural constituent of epidermisNASmolecular_function
GO:0045110Intermediate filament bundle assemblyIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73667712090.80593504430.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1349929396
GSE13712_SHEARUp0.0685742278
GSE13712_STATICDown-0.0053658669
GSE19018Up0.1859047198
GSE19899_A1Down-0.0653048954
GSE19899_A2Up0.1352334727
PubMed_21979375_A1Up0.3456311540
PubMed_21979375_A2Down-0.1103345157
GSE35957Up0.0518690164
GSE36640Down-0.0422947843
GSE54402Up0.0506971756
GSE9593Up0.0192571263
GSE43922Up0.0252582935
GSE24585Down-0.0539405973
GSE37065Up0.1320285131
GSE28863_A1Down-0.0778272225
GSE28863_A2Up0.0070371796
GSE28863_A3Up0.2340818078
GSE28863_A4Up0.0434104859
GSE48662Down-0.1528636852

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019417MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.