HCSGD entry for PKP1

1. General information

Official gene symbolPKP1
Entrez ID5317
Gene full nameplakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
Other gene symbolsB6P
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005521Lamin bindingIDAmolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005882Intermediate filamentTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007155Cell adhesionNASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0019215Intermediate filament bindingNASmolecular_function
GO:0030057DesmosomeNAScellular_component
GO:0030280Structural constituent of epidermisNASmolecular_function
GO:0045110Intermediate filament bundle assemblyIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73667712090.80593504430.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1349929396
GSE13712_SHEARUp0.0685742278
GSE13712_STATICDown-0.0053658669
GSE19018Up0.1859047198
GSE19899_A1Down-0.0653048954
GSE19899_A2Up0.1352334727
PubMed_21979375_A1Up0.3456311540
PubMed_21979375_A2Down-0.1103345157
GSE35957Up0.0518690164
GSE36640Down-0.0422947843
GSE54402Up0.0506971756
GSE9593Up0.0192571263
GSE43922Up0.0252582935
GSE24585Down-0.0539405973
GSE37065Up0.1320285131
GSE28863_A1Down-0.0778272225
GSE28863_A2Up0.0070371796
GSE28863_A3Up0.2340818078
GSE28863_A4Up0.0434104859
GSE48662Down-0.1528636852

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019417MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.