HCSGD entry for PKD2

1. General information

Official gene symbolPKD2
Entrez ID5311
Gene full namepolycystic kidney disease 2 (autosomal dominant)
Other gene symbolsAPKD2 PC2 PKD4 Pc-2 TRPP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001658Branching involved in ureteric bud morphogenesisIEPbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001889Liver developmentIEA IEPbiological_process
GO:0001892Embryonic placenta developmentIEA ISSbiological_process
GO:0001947Heart loopingIMPbiological_process
GO:0002133Polycystin complexIEA ISScellular_component
GO:0003127Detection of nodal flowIEA ISSbiological_process
GO:0005102Receptor bindingIEA IPImolecular_function
GO:0005244Voltage-gated ion channel activityIDAmolecular_function
GO:0005245Voltage-gated calcium channel activityIDAmolecular_function
GO:0005248Voltage-gated sodium channel activityIDAmolecular_function
GO:0005267Potassium channel activityIEA ISSmolecular_function
GO:0005509Calcium ion bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDA IMPcellular_component
GO:0005783Endoplasmic reticulumIDA IEA IMPcellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005911Cell-cell junctionIEA ISScellular_component
GO:0005929CiliumISScellular_component
GO:0006816Calcium ion transportIDA ISSbiological_process
GO:0007050Cell cycle arrestIEA ISSbiological_process
GO:0007259JAK-STAT cascadeIEA ISSbiological_process
GO:0007368Determination of left/right symmetryISSbiological_process
GO:0007507Heart developmentIEA IEPbiological_process
GO:0008092Cytoskeletal protein bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationNASbiological_process
GO:0009925Basal plasma membraneIDAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0021510Spinal cord developmentIEPbiological_process
GO:0021915Neural tube developmentIEPbiological_process
GO:0022843Voltage-gated cation channel activityIDAmolecular_function
GO:0030027LamellipodiumIDAcellular_component
GO:0030814Regulation of cAMP metabolic processIEA ISSbiological_process
GO:0031512Motile primary ciliumIEA ISScellular_component
GO:0031513Nonmotile primary ciliumIEA ISScellular_component
GO:0031587Positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityIMPbiological_process
GO:0031659Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleIDAbiological_process
GO:0031941Filamentous actinIDAcellular_component
GO:0034614Cellular response to reactive oxygen speciesNASbiological_process
GO:0035502Metanephric part of ureteric bud developmentIEPbiological_process
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0035904Aorta developmentIEPbiological_process
GO:0036064Ciliary basal bodyIDAcellular_component
GO:0042127Regulation of cell proliferationIMPbiological_process
GO:0042802Identical protein bindingIEA IPI ISSmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042805Actinin bindingIDAmolecular_function
GO:0042994Cytoplasmic sequestering of transcription factorIMPbiological_process
GO:0043398HLH domain bindingIPImolecular_function
GO:0044325Ion channel bindingIPImolecular_function
GO:0045180Basal cortexIDA IEAcellular_component
GO:0045429Positive regulation of nitric oxide biosynthetic processIEA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0048763Calcium-induced calcium release activityIDAmolecular_function
GO:0050982Detection of mechanical stimulusIBA IEA ISSbiological_process
GO:0051117ATPase bindingIEA ISSmolecular_function
GO:0051209Release of sequestered calcium ion into cytosolIDA IEA IMPbiological_process
GO:0051298Centrosome duplicationNASbiological_process
GO:0051371Muscle alpha-actinin bindingIEAmolecular_function
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIEA ISSbiological_process
GO:0060674Placenta blood vessel developmentIEA ISSbiological_process
GO:0061333Renal tubule morphogenesisIEA ISSbiological_process
GO:0061441Renal artery morphogenesisIEPbiological_process
GO:0070588Calcium ion transmembrane transportIDAbiological_process
GO:0071158Positive regulation of cell cycle arrestIMPbiological_process
GO:0071458Integral component of cytoplasmic side of endoplasmic reticulum membraneIDAcellular_component
GO:0071464Cellular response to hydrostatic pressureIDAbiological_process
GO:0071470Cellular response to osmotic stressIDAbiological_process
GO:0071498Cellular response to fluid shear stressIEA IMPbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneIDAcellular_component
GO:0071910Determination of liver left/right asymmetryIMPbiological_process
GO:0072075Metanephric mesenchyme developmentIEPbiological_process
GO:0072164Mesonephric tubule developmentIEPbiological_process
GO:0072177Mesonephric duct developmentIEPbiological_process
GO:0072208Metanephric smooth muscle tissue developmentIEPbiological_process
GO:0072214Metanephric cortex developmentIEPbiological_process
GO:0072218Metanephric ascending thin limb developmentIEPbiological_process
GO:0072219Metanephric cortical collecting duct developmentIEPbiological_process
GO:0072235Metanephric distal tubule developmentIEPbiological_process
GO:0072284Metanephric S-shaped body morphogenesisIEPbiological_process
GO:0072686Mitotic spindleIDA IEAcellular_component
GO:0090279Regulation of calcium ion importIDAbiological_process
GO:2000134Negative regulation of G1/S transition of mitotic cell cycleIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89034142320.00358974200.99999024730.1217597938

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8259774968
GSE13712_SHEARDown-0.2382284923
GSE13712_STATICDown-0.1695767183
GSE19018Down-0.5686898005
GSE19899_A1Down-1.4045975307
GSE19899_A2Down-0.8042723091
PubMed_21979375_A1Down-2.2344309205
PubMed_21979375_A2Down-0.7665441165
GSE35957Up0.8470225253
GSE36640Up0.0257995679
GSE54402Down-0.5109994153
GSE9593Up0.7445709413
GSE43922Down-0.8190546813
GSE24585Up0.5091153890
GSE37065Up0.0304672099
GSE28863_A1Down-0.3693809059
GSE28863_A2Up0.3524524158
GSE28863_A3Down-0.6722073868
GSE28863_A4Down-0.1231129619
GSE48662Down-0.1761899183

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT001158Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19821056
hsa-miR-106b-5pMIMAT0000680MIRT020485Western blotFunctional MTI20709030
hsa-miR-93-5pMIMAT0000093MIRT028086SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT029117MicroarrayFunctional MTI (Weak)19088304
hsa-miR-21-5pMIMAT0000076MIRT030759MicroarrayFunctional MTI (Weak)18591254
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.