HCSGD entry for PKD2

1. General information

Official gene symbolPKD2
Entrez ID5311
Gene full namepolycystic kidney disease 2 (autosomal dominant)
Other gene symbolsAPKD2 PC2 PKD4 Pc-2 TRPP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001658Branching involved in ureteric bud morphogenesisIEPbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001889Liver developmentIEA IEPbiological_process
GO:0001892Embryonic placenta developmentIEA ISSbiological_process
GO:0001947Heart loopingIMPbiological_process
GO:0002133Polycystin complexIEA ISScellular_component
GO:0003127Detection of nodal flowIEA ISSbiological_process
GO:0005102Receptor bindingIEA IPImolecular_function
GO:0005244Voltage-gated ion channel activityIDAmolecular_function
GO:0005245Voltage-gated calcium channel activityIDAmolecular_function
GO:0005248Voltage-gated sodium channel activityIDAmolecular_function
GO:0005267Potassium channel activityIEA ISSmolecular_function
GO:0005509Calcium ion bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDA IMPcellular_component
GO:0005783Endoplasmic reticulumIDA IEA IMPcellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005911Cell-cell junctionIEA ISScellular_component
GO:0005929CiliumISScellular_component
GO:0006816Calcium ion transportIDA ISSbiological_process
GO:0007050Cell cycle arrestIEA ISSbiological_process
GO:0007259JAK-STAT cascadeIEA ISSbiological_process
GO:0007368Determination of left/right symmetryISSbiological_process
GO:0007507Heart developmentIEA IEPbiological_process
GO:0008092Cytoskeletal protein bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationNASbiological_process
GO:0009925Basal plasma membraneIDAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0021510Spinal cord developmentIEPbiological_process
GO:0021915Neural tube developmentIEPbiological_process
GO:0022843Voltage-gated cation channel activityIDAmolecular_function
GO:0030027LamellipodiumIDAcellular_component
GO:0030814Regulation of cAMP metabolic processIEA ISSbiological_process
GO:0031512Motile primary ciliumIEA ISScellular_component
GO:0031513Nonmotile primary ciliumIEA ISScellular_component
GO:0031587Positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityIMPbiological_process
GO:0031659Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleIDAbiological_process
GO:0031941Filamentous actinIDAcellular_component
GO:0034614Cellular response to reactive oxygen speciesNASbiological_process
GO:0035502Metanephric part of ureteric bud developmentIEPbiological_process
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0035904Aorta developmentIEPbiological_process
GO:0036064Ciliary basal bodyIDAcellular_component
GO:0042127Regulation of cell proliferationIMPbiological_process
GO:0042802Identical protein bindingIEA IPI ISSmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042805Actinin bindingIDAmolecular_function
GO:0042994Cytoplasmic sequestering of transcription factorIMPbiological_process
GO:0043398HLH domain bindingIPImolecular_function
GO:0044325Ion channel bindingIPImolecular_function
GO:0045180Basal cortexIDA IEAcellular_component
GO:0045429Positive regulation of nitric oxide biosynthetic processIEA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0048763Calcium-induced calcium release activityIDAmolecular_function
GO:0050982Detection of mechanical stimulusIBA IEA ISSbiological_process
GO:0051117ATPase bindingIEA ISSmolecular_function
GO:0051209Release of sequestered calcium ion into cytosolIDA IEA IMPbiological_process
GO:0051298Centrosome duplicationNASbiological_process
GO:0051371Muscle alpha-actinin bindingIEAmolecular_function
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIEA ISSbiological_process
GO:0060674Placenta blood vessel developmentIEA ISSbiological_process
GO:0061333Renal tubule morphogenesisIEA ISSbiological_process
GO:0061441Renal artery morphogenesisIEPbiological_process
GO:0070588Calcium ion transmembrane transportIDAbiological_process
GO:0071158Positive regulation of cell cycle arrestIMPbiological_process
GO:0071458Integral component of cytoplasmic side of endoplasmic reticulum membraneIDAcellular_component
GO:0071464Cellular response to hydrostatic pressureIDAbiological_process
GO:0071470Cellular response to osmotic stressIDAbiological_process
GO:0071498Cellular response to fluid shear stressIEA IMPbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneIDAcellular_component
GO:0071910Determination of liver left/right asymmetryIMPbiological_process
GO:0072075Metanephric mesenchyme developmentIEPbiological_process
GO:0072164Mesonephric tubule developmentIEPbiological_process
GO:0072177Mesonephric duct developmentIEPbiological_process
GO:0072208Metanephric smooth muscle tissue developmentIEPbiological_process
GO:0072214Metanephric cortex developmentIEPbiological_process
GO:0072218Metanephric ascending thin limb developmentIEPbiological_process
GO:0072219Metanephric cortical collecting duct developmentIEPbiological_process
GO:0072235Metanephric distal tubule developmentIEPbiological_process
GO:0072284Metanephric S-shaped body morphogenesisIEPbiological_process
GO:0072686Mitotic spindleIDA IEAcellular_component
GO:0090279Regulation of calcium ion importIDAbiological_process
GO:2000134Negative regulation of G1/S transition of mitotic cell cycleIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89034142320.00358974200.99999024730.1217597938

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8259774968
GSE13712_SHEARDown-0.2382284923
GSE13712_STATICDown-0.1695767183
GSE19018Down-0.5686898005
GSE19899_A1Down-1.4045975307
GSE19899_A2Down-0.8042723091
PubMed_21979375_A1Down-2.2344309205
PubMed_21979375_A2Down-0.7665441165
GSE35957Up0.8470225253
GSE36640Up0.0257995679
GSE54402Down-0.5109994153
GSE9593Up0.7445709413
GSE43922Down-0.8190546813
GSE24585Up0.5091153890
GSE37065Up0.0304672099
GSE28863_A1Down-0.3693809059
GSE28863_A2Up0.3524524158
GSE28863_A3Down-0.6722073868
GSE28863_A4Down-0.1231129619
GSE48662Down-0.1761899183

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT001158Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19821056
hsa-miR-106b-5pMIMAT0000680MIRT020485Western blotFunctional MTI20709030
hsa-miR-93-5pMIMAT0000093MIRT028086SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT029117MicroarrayFunctional MTI (Weak)19088304
hsa-miR-21-5pMIMAT0000076MIRT030759MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.