HCSGD entry for PIK3R2

1. General information

Official gene symbolPIK3R2
Entrez ID5296
Gene full namephosphoinositide-3-kinase, regulatory subunit 2 (beta)
Other gene symbolsMPPH P85B p85 p85-BETA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIEAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:00163031-phosphatidylinositol-3-kinase activityISSmolecular_function
GO:0016310PhosphorylationISSbiological_process
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0035014Phosphatidylinositol 3-kinase regulator activityIEAmolecular_function
GO:0036092Phosphatidylinositol-3-phosphate biosynthetic processISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationISSbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07039643250.90922209260.56681079841.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0451557449
GSE13712_SHEARDown-0.2043883711
GSE13712_STATICUp0.1380019383
GSE19018Up0.1792793765
GSE19899_A1Down-0.1311200109
GSE19899_A2Up0.5424764630
PubMed_21979375_A1Down-0.0477077986
PubMed_21979375_A2Up0.6826716838
GSE35957Down-0.1085428622
GSE36640Up0.5236813752
GSE54402Up0.4063719174
GSE9593Up0.2373850147
GSE43922Up0.0026328648
GSE24585Down-0.3488274840
GSE37065Down-0.1430940738
GSE28863_A1Up0.5945245569
GSE28863_A2Up0.3682338592
GSE28863_A3Up0.4668138783
GSE28863_A4Up0.0183702476
GSE48662Down-0.1009377707

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SF1126DB05210 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-126-3pMIMAT0000445MIRT003894Luciferase reporter assay//Western blotFunctional MTI18987025
hsa-miR-126-3pMIMAT0000445MIRT003894Western blot//qRT-PCR//Luciferase reporter assayFunctional MTI18663744
hsa-miR-126-3pMIMAT0000445MIRT003894Reporter assay;Western blotFunctional MTI21249429
hsa-miR-30c-5pMIMAT0000244MIRT007136qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-133a-3pMIMAT0000427MIRT021712Reporter assayNon-Functional MTI21249429
hsa-miR-296-3pMIMAT0004679MIRT038442CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048832CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-126-3pMIMAT00004451hsa-miR-126{Western blot}{overexpression by miRNA precursor transfection}18663744
hsa-miR-126-3pMIMAT0000445NAhsa-miR-126{Western blot}{endogenous}21249429
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.