HCSGD entry for PIK3R2

1. General information

Official gene symbolPIK3R2
Entrez ID5296
Gene full namephosphoinositide-3-kinase, regulatory subunit 2 (beta)
Other gene symbolsMPPH P85B p85 p85-BETA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIEAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:00163031-phosphatidylinositol-3-kinase activityISSmolecular_function
GO:0016310PhosphorylationISSbiological_process
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0035014Phosphatidylinositol 3-kinase regulator activityIEAmolecular_function
GO:0036092Phosphatidylinositol-3-phosphate biosynthetic processISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationISSbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07039643250.90922209260.56681079841.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0451557449
GSE13712_SHEARDown-0.2043883711
GSE13712_STATICUp0.1380019383
GSE19018Up0.1792793765
GSE19899_A1Down-0.1311200109
GSE19899_A2Up0.5424764630
PubMed_21979375_A1Down-0.0477077986
PubMed_21979375_A2Up0.6826716838
GSE35957Down-0.1085428622
GSE36640Up0.5236813752
GSE54402Up0.4063719174
GSE9593Up0.2373850147
GSE43922Up0.0026328648
GSE24585Down-0.3488274840
GSE37065Down-0.1430940738
GSE28863_A1Up0.5945245569
GSE28863_A2Up0.3682338592
GSE28863_A3Up0.4668138783
GSE28863_A4Up0.0183702476
GSE48662Down-0.1009377707

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SF1126DB05210 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-126-3pMIMAT0000445MIRT003894Luciferase reporter assay//Western blotFunctional MTI18987025
hsa-miR-126-3pMIMAT0000445MIRT003894Western blot//qRT-PCR//Luciferase reporter assayFunctional MTI18663744
hsa-miR-126-3pMIMAT0000445MIRT003894Reporter assay;Western blotFunctional MTI21249429
hsa-miR-30c-5pMIMAT0000244MIRT007136qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-133a-3pMIMAT0000427MIRT021712Reporter assayNon-Functional MTI21249429
hsa-miR-296-3pMIMAT0004679MIRT038442CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048832CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-126-3pMIMAT00004451hsa-miR-126{Western blot}{overexpression by miRNA precursor transfection}18663744
hsa-miR-126-3pMIMAT0000445NAhsa-miR-126{Western blot}{endogenous}21249429
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.