HCSGD entry for PIK3CG

1. General information

Official gene symbolPIK3CG
Entrez ID5294
Gene full namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other gene symbolsPI3CG PI3K PI3Kgamma PIK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001816Cytokine productionTASbiological_process
GO:0002250Adaptive immune responseTASbiological_process
GO:0002407Dendritic cell chemotaxisTASbiological_process
GO:0002675Positive regulation of acute inflammatory responseIEAbiological_process
GO:0002679Respiratory burst involved in defense responseTASbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIEAcellular_component
GO:00059441-phosphatidylinositol-4-phosphate 3-kinase, class IB complexIDAcellular_component
GO:0006468Protein phosphorylationIEAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010818T cell chemotaxisTASbiological_process
GO:0010897Negative regulation of triglyceride catabolic processIEAbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIDA TASbiological_process
GO:0016020MembraneIDAcellular_component
GO:00163031-phosphatidylinositol-3-kinase activityIBA IEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030593Neutrophil chemotaxisTASbiological_process
GO:0032252Secretory granule localizationIEAbiological_process
GO:0033628Regulation of cell adhesion mediated by integrinTASbiological_process
GO:0035004Phosphatidylinositol 3-kinase activityTASmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activityIBAmolecular_function
GO:0035747Natural killer cell chemotaxisTASbiological_process
GO:0042098T cell proliferationTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0042629Mast cell granuleTAScellular_component
GO:0043303Mast cell degranulationTASbiological_process
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046875Ephrin receptor bindingIPImolecular_function
GO:0046934Phosphatidylinositol-4,5-bisphosphate 3-kinase activityIBAmolecular_function
GO:0048015Phosphatidylinositol-mediated signalingIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0055118Negative regulation of cardiac muscle contractionTASbiological_process
GO:0070527Platelet aggregationTASbiological_process
GO:0072672Neutrophil extravasationTASbiological_process
GO:0097284Hepatocyte apoptotic processIEAbiological_process
GO:2000270Negative regulation of fibroblast apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01064702330.94049389840.26215182411.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0003146839
GSE13712_SHEARDown-0.7272125461
GSE13712_STATICDown-0.2835784648
GSE19018Up0.0392906863
GSE19899_A1Up0.4103053076
GSE19899_A2Up1.6691613371
PubMed_21979375_A1Up2.3062662419
PubMed_21979375_A2Up1.1656276909
GSE35957Up0.0425856159
GSE36640Up0.4207691200
GSE54402Up0.8748172251
GSE9593Up0.0700739084
GSE43922Up1.8917887748
GSE24585Up0.0026443069
GSE37065Up0.0586767746
GSE28863_A1Down-0.1745447174
GSE28863_A2Down-0.0134579178
GSE28863_A3Up0.1010259701
GSE28863_A4Down-0.0472557428
GSE48662Up0.1894040346

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

StaurosporineDB02010 EXPT02970 | EXPT02972
2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-OneDB02656 EXPT02073
QuercetinDB04216 EXPT02732
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONEDB04769 -
XL765DB05241 -
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONEDB06831 -
N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDEDB06836 -
5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-oneDB07073 -
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOLDB07335 -
(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONEDB07503 -
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATEDB08059 -
1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amineDB08300 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019349MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT029342MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22120720Protein kinase-Ciota (PKCiota) is a member of the atypical PKC family and an important downstream mediator in the phosphoinositide-3-kinase (PI-3-kinase) pathway
22120720Activation of the PI-3-kinase pathway by introduction of mutant, oncogenic PIK3CA into breast mammary epithelial cells increased both the expression and activation of PKCiota
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