HCSGD entry for PIK3CG

1. General information

Official gene symbolPIK3CG
Entrez ID5294
Gene full namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other gene symbolsPI3CG PI3K PI3Kgamma PIK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001816Cytokine productionTASbiological_process
GO:0002250Adaptive immune responseTASbiological_process
GO:0002407Dendritic cell chemotaxisTASbiological_process
GO:0002675Positive regulation of acute inflammatory responseIEAbiological_process
GO:0002679Respiratory burst involved in defense responseTASbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIEAcellular_component
GO:00059441-phosphatidylinositol-4-phosphate 3-kinase, class IB complexIDAcellular_component
GO:0006468Protein phosphorylationIEAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010818T cell chemotaxisTASbiological_process
GO:0010897Negative regulation of triglyceride catabolic processIEAbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIDA TASbiological_process
GO:0016020MembraneIDAcellular_component
GO:00163031-phosphatidylinositol-3-kinase activityIBA IEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030593Neutrophil chemotaxisTASbiological_process
GO:0032252Secretory granule localizationIEAbiological_process
GO:0033628Regulation of cell adhesion mediated by integrinTASbiological_process
GO:0035004Phosphatidylinositol 3-kinase activityTASmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activityIBAmolecular_function
GO:0035747Natural killer cell chemotaxisTASbiological_process
GO:0042098T cell proliferationTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0042629Mast cell granuleTAScellular_component
GO:0043303Mast cell degranulationTASbiological_process
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046875Ephrin receptor bindingIPImolecular_function
GO:0046934Phosphatidylinositol-4,5-bisphosphate 3-kinase activityIBAmolecular_function
GO:0048015Phosphatidylinositol-mediated signalingIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0055118Negative regulation of cardiac muscle contractionTASbiological_process
GO:0070527Platelet aggregationTASbiological_process
GO:0072672Neutrophil extravasationTASbiological_process
GO:0097284Hepatocyte apoptotic processIEAbiological_process
GO:2000270Negative regulation of fibroblast apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01064702330.94049389840.26215182411.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0003146839
GSE13712_SHEARDown-0.7272125461
GSE13712_STATICDown-0.2835784648
GSE19018Up0.0392906863
GSE19899_A1Up0.4103053076
GSE19899_A2Up1.6691613371
PubMed_21979375_A1Up2.3062662419
PubMed_21979375_A2Up1.1656276909
GSE35957Up0.0425856159
GSE36640Up0.4207691200
GSE54402Up0.8748172251
GSE9593Up0.0700739084
GSE43922Up1.8917887748
GSE24585Up0.0026443069
GSE37065Up0.0586767746
GSE28863_A1Down-0.1745447174
GSE28863_A2Down-0.0134579178
GSE28863_A3Up0.1010259701
GSE28863_A4Down-0.0472557428
GSE48662Up0.1894040346

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

StaurosporineDB02010 EXPT02970 | EXPT02972
2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-OneDB02656 EXPT02073
QuercetinDB04216 EXPT02732
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONEDB04769 -
XL765DB05241 -
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONEDB06831 -
N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDEDB06836 -
5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-oneDB07073 -
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOLDB07335 -
(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONEDB07503 -
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATEDB08059 -
1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amineDB08300 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019349MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT029342MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22120720Protein kinase-Ciota (PKCiota) is a member of the atypical PKC family and an important downstream mediator in the phosphoinositide-3-kinase (PI-3-kinase) pathway
22120720Activation of the PI-3-kinase pathway by introduction of mutant, oncogenic PIK3CA into breast mammary epithelial cells increased both the expression and activation of PKCiota
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